Transcranial focused ultrasound for the treatment of tremor: A preliminary case series.
Brain Stimul
; 17(1): 35-38, 2024.
Article
in En
| MEDLINE
| ID: mdl-38128826
ABSTRACT
BACKGROUND:
Essential tremor (ET) can be debilitating. Treatments for ET include beta-blockers and surgical interventions. Low-intensity focused ultrasound (LIFU) may offer an office-based non-invasive alternative.OBJECTIVE:
This pilot open label clinical trial explores safety, feasibility, and potential efficacy of LIFU in treatment of ET.METHODS:
We report outcomes from the first 10 participants in this IRB-approved trial of LIFU for treatment of ET. The ventral intermediate nucleus of the thalamus (Vim) was targeted using structural and functional MRI. Participants underwent eight 10-min sessions of LIFU targeting the contralateral (Vim) to the most affected hand. Safety was closely monitored; Global Rating of Change (GRC) and The Essential Tremor Rating Scale (TETRAS) scores were collected.RESULTS:
No adverse effects were reported. Eight participants reported a GRC ≥2. TETRAS performance subscale demonstrated clinically significant improvement in all participants.CONCLUSION:
Preliminary findings support LIFU's safety and feasibility. The potential efficacy encourages additional sham-controlled studies.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Tremor
/
Essential Tremor
Limits:
Humans
Language:
En
Journal:
Brain Stimul
Journal subject:
CEREBRO
Year:
2024
Document type:
Article