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New insights into the correlations between circulating tumor cells and target organ metastasis.
Zhan, Qinru; Liu, Bixia; Situ, Xiaohua; Luo, Yuting; Fu, Tongze; Wang, Yanxia; Xie, Zhongpeng; Ren, Lijuan; Zhu, Ying; He, Weiling; Ke, Zunfu.
Affiliation
  • Zhan Q; Department of Pathology, The First Affiliated Hospital of Sun Yat-sen University, 510000, Guangzhou, Guangdong, P.R. China.
  • Liu B; Department of Pathology, The First Affiliated Hospital of Sun Yat-sen University, 510000, Guangzhou, Guangdong, P.R. China.
  • Situ X; Department of Pathology, The First Affiliated Hospital of Sun Yat-sen University, 510000, Guangzhou, Guangdong, P.R. China.
  • Luo Y; Department of Pathology, The First Affiliated Hospital of Sun Yat-sen University, 510000, Guangzhou, Guangdong, P.R. China.
  • Fu T; Department of Pathology, The First Affiliated Hospital of Sun Yat-sen University, 510000, Guangzhou, Guangdong, P.R. China.
  • Wang Y; Institute of Precision Medicine, The First Affiliated Hospital of Sun Yat-sen University, 510000, Guangzhou, Guangdong, P.R. China.
  • Xie Z; Zhongshan School of Medicine, Sun Yat-sen University, 510000, Guangzhou, Guangdong, P.R. China.
  • Ren L; Zhongshan School of Medicine, Sun Yat-sen University, 510000, Guangzhou, Guangdong, P.R. China.
  • Zhu Y; Department of Pathology, The First Affiliated Hospital of Sun Yat-sen University, 510000, Guangzhou, Guangdong, P.R. China.
  • He W; Department of Radiology, The First Affiliated Hospital of Sun Yat-sen University, 510000, Guangzhou, Guangdong, P.R. China. zhuy45@mail.sysu.edu.cn.
  • Ke Z; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, 10065, USA. hewling@mail.sysu.edu.cn.
Signal Transduct Target Ther ; 8(1): 465, 2023 12 21.
Article in En | MEDLINE | ID: mdl-38129401
ABSTRACT
Organ-specific metastasis is the primary cause of cancer patient death. The distant metastasis of tumor cells to specific organs depends on both the intrinsic characteristics of the tumor cells and extrinsic factors in their microenvironment. During an intermediate stage of metastasis, circulating tumor cells (CTCs) are released into the bloodstream from primary and metastatic tumors. CTCs harboring aggressive or metastatic features can extravasate to remote sites for continuous colonizing growth, leading to further lesions. In the past decade, numerous studies demonstrated that CTCs exhibited huge clinical value including predicting distant metastasis, assessing prognosis and monitoring treatment response et al. Furthermore, increasingly numerous experiments are dedicated to identifying the key molecules on or inside CTCs and exploring how they mediate CTC-related organ-specific metastasis. Based on the above molecules, more and more inhibitors are being developed to target CTCs and being utilized to completely clean CTCs, which should provide promising prospects to administer advanced tumor. Recently, the application of various nanomaterials and microfluidic technologies in CTCs enrichment technology has assisted to improve our deep insights into the phenotypic characteristics and biological functions of CTCs as a potential therapy target, which may pave the way for us to make practical clinical strategies. In the present review, we mainly focus on the role of CTCs being involved in targeted organ metastasis, especially the latest molecular mechanism research and clinical intervention strategies related to CTCs.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Nanostructures / Neoplastic Cells, Circulating Limits: Humans Language: En Journal: Signal Transduct Target Ther Year: 2023 Document type: Article Country of publication: United kingdom

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Nanostructures / Neoplastic Cells, Circulating Limits: Humans Language: En Journal: Signal Transduct Target Ther Year: 2023 Document type: Article Country of publication: United kingdom