Examining the functional space of gut microbiome-derived peptides.
Microbiologyopen
; 12(6): e1393, 2023 12.
Article
in En
| MEDLINE
| ID: mdl-38129980
ABSTRACT
The human gut microbiome contains thousands of small, novel peptides that could play a role in microbe-microbe and host-microbe interactions, contributing to human health and disease. Although these peptides have not yet been systematically characterized, computational tools can be used to elucidate the bioactivities they may have. This article proposes probing the functional space of gut microbiome-derived peptides (MDPs) using in silico approaches for three bioactivities antimicrobial, anticancer, and nucleomodulins. Machine learning programs that support peptide and protein queries are provided for each bioactivity. Considering the biases of an activity-centric approach, activity-agnostic tools using structural and chemical similarity and target prediction are also described. Gut MDPs represent a vast functional space that can not only contribute to our understanding of microbiome interactions but potentially even serve as a source of life-changing therapeutics.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Microbiota
/
Gastrointestinal Microbiome
/
Anti-Infective Agents
Limits:
Humans
Language:
En
Journal:
Microbiologyopen
Year:
2023
Document type:
Article
Affiliation country:
United States