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Sex, Endothelial Cell Functions, and Peripheral Artery Disease.
Cartland, Siân P; Stanley, Christopher P; Bursill, Christina; Passam, Freda; Figtree, Gemma A; Patel, Sanjay; Loa, Jacky; Golledge, Jonathan; Robinson, David A; Aitken, Sarah J; Kavurma, Mary M.
Affiliation
  • Cartland SP; Heart Research Institute, The University of Sydney, Sydney, NSW 2042, Australia.
  • Stanley CP; Heart Research Institute, The University of Sydney, Sydney, NSW 2042, Australia.
  • Bursill C; South Australian Health and Medical Research Institute, Adelaide, SA 5000, Australia.
  • Passam F; Adelaide Medical School, University of Adelaide, Adelaide, SA 5005, Australia.
  • Figtree GA; Faculty of Health and Medicine, The University of Sydney, Sydney, NSW 2050, Australia.
  • Patel S; Faculty of Health and Medicine, The University of Sydney, Sydney, NSW 2050, Australia.
  • Loa J; Kolling Institute of Medical Research, Sydney, NSW 2064, Australia.
  • Golledge J; Heart Research Institute, The University of Sydney, Sydney, NSW 2042, Australia.
  • Robinson DA; Royal Prince Alfred Hospital, Sydney, NSW 2050, Australia.
  • Aitken SJ; Royal Prince Alfred Hospital, Sydney, NSW 2050, Australia.
  • Kavurma MM; Queensland Research Centre for Peripheral Vascular Disease, College of Medicine and Dentistry, James Cook University, Townsville, QLD 4811, Australia.
Int J Mol Sci ; 24(24)2023 Dec 13.
Article in En | MEDLINE | ID: mdl-38139267
ABSTRACT
Peripheral artery disease (PAD) is caused by blocked arteries due to atherosclerosis and/or thrombosis which reduce blood flow to the lower limbs. It results in major morbidity, including ischemic limb, claudication, and amputation, with patients also suffering a heightened risk of heart attack, stroke, and death. Recent studies suggest women have a higher prevalence of PAD than men, and with worse outcomes after intervention. In addition to a potential unconscious bias faced by women with PAD in the health system, with underdiagnosis, and lower rates of guideline-based therapy, fundamental biological differences between men and women may be important. In this review, we highlight sexual dimorphisms in endothelial cell functions and how they may impact PAD pathophysiology in women. Understanding sex-specific mechanisms in PAD is essential for the development of new therapies and personalized care for patients with PAD.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Atherosclerosis / Peripheral Arterial Disease Limits: Female / Humans / Male Language: En Journal: Int J Mol Sci Year: 2023 Document type: Article Affiliation country: Australia
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Atherosclerosis / Peripheral Arterial Disease Limits: Female / Humans / Male Language: En Journal: Int J Mol Sci Year: 2023 Document type: Article Affiliation country: Australia