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Clinical features of anti-pituitary-specific transcription factor-1 (PIT-1) hypophysitis: a new aspect of paraneoplastic autoimmune condition.
Urai, Shin; Iguchi, Genzo; Kanie, Keitaro; Bando, Hironori; Yamamoto, Masaaki; Oi, Yuka; Kashitani, Yuya; Iida, Keiji; Kanzawa, Maki; Fukuoka, Hidenori; Takahashi, Michiko; Shintani, Yasushi; Ogawa, Wataru; Takahashi, Yutaka.
Affiliation
  • Urai S; Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Hyogo 650-0017, Japan.
  • Iguchi G; Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Hyogo 650-0017, Japan.
  • Kanie K; Medical Center for Student Health, Kobe University, Kobe, Hyogo 657-8501, Japan.
  • Bando H; Division of Biosignal Pathophysiology, Kobe University, Kobe, Hyogo 657-8501, Japan.
  • Yamamoto M; Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Hyogo 650-0017, Japan.
  • Oi Y; Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Hospital, Kobe, Hyogo 650-0017, Japan.
  • Kashitani Y; Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Hyogo 650-0017, Japan.
  • Iida K; Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Hyogo 650-0017, Japan.
  • Kanzawa M; Division of Diabetes and Endocrinology, Hyogo Prefectural Kakogawa Medical Center, Kakogawa, Hyogo 675-8555, Japan.
  • Fukuoka H; Division of Diabetes and Endocrinology, Hyogo Prefectural Kakogawa Medical Center, Kakogawa, Hyogo 675-8555, Japan.
  • Takahashi M; Division of Diagnostic Pathology, Kobe University Graduate School of Medicine, Kobe, Hyogo 650-0017, Japan.
  • Shintani Y; Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Hospital, Kobe, Hyogo 650-0017, Japan.
  • Ogawa W; Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Hospital, Kobe, Hyogo 650-0017, Japan.
  • Takahashi Y; Department of Nutrition, Kobe University Hospital, Kobe, Hyogo 650-0017, Japan.
Eur J Endocrinol ; 190(1): K1-K7, 2024 Jan 03.
Article in En | MEDLINE | ID: mdl-38146732
ABSTRACT
The pathogenesis of anti-pituitary-specific transcription factor-1 (PIT-1) hypophysitis was gradually revealed as cases emerged. Our comprehensive analysis, including all reported cases, identified a new instance of anti-PIT-1 hypophysitis postimmune checkpoint inhibitor therapy. All 9 patients exhibited extremely low growth hormone (GH), prolactin (PRL), and thyroid-stimulating hormone (TSH) levels; 2 had a slightly atrophic pituitary gland; 4 had thymoma, and 5 had malignant neoplasms of diffuse large B-cell lymphoma (DLBCL) and other origins. Patients with thymoma showed multiple autoimmune diseases. HLA-A*2402 and/or A*0206 were present in six and DR53 in 5 cases analyzed. High anti-PIT-1 antibody titers and ectopic PIT-1 expression in the cytosol and nucleus of the tumor tissues were observed in patients with thymoma or DLBCL, whereas it was exclusively observed in the nuclei of a bladder cancer patient. These findings provide new insights into the pathophysiology of paraneoplastic autoimmune hypophysitis.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autoimmune Diseases / Thymoma / Thymus Neoplasms / Autoimmune Hypophysitis / Hypophysitis Limits: Humans Language: En Journal: Eur J Endocrinol Journal subject: ENDOCRINOLOGIA Year: 2024 Document type: Article Affiliation country: Japan Country of publication: United kingdom
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autoimmune Diseases / Thymoma / Thymus Neoplasms / Autoimmune Hypophysitis / Hypophysitis Limits: Humans Language: En Journal: Eur J Endocrinol Journal subject: ENDOCRINOLOGIA Year: 2024 Document type: Article Affiliation country: Japan Country of publication: United kingdom