[Environmental pollutants and Alzheimer's disease].
Sheng Li Xue Bao
; 75(6): 740-766, 2023 Dec 25.
Article
in Zh
| MEDLINE
| ID: mdl-38151341
ABSTRACT
Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive cognitive impairment. The main hypotheses about the pathogenesis of AD include the hypothesis of ß-amyloid protein, the hypothesis of abnormal phosphorylation of Tau protein, and the hypothesis of neuroinflammation. In recent years, environmental pollutants have been considered as an important factor in causing neurological dysfunction. Common environmental pollutants include heavy metals, pesticides, polychlorinated biphenyls, microplastics, and air pollutants, all of which have been proven to have neurotoxicity. In this review, we not only discussed epidemiological and animal experimental studies that link environmental pollution with AD, but also summarized the mechanisms of action of relevant toxins, providing insights for studying the interrelationships between environmental pollutants and AD.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Neurodegenerative Diseases
/
Environmental Pollutants
/
Alzheimer Disease
Limits:
Animals
Language:
Zh
Journal:
Sheng Li Xue Bao
Year:
2023
Document type:
Article
Affiliation country:
China