An ATM D-compartmentalization in DNA damage response.

Prasad, Anjali; Kanakkanthara, Arun

Prasad, Anjali; Kanakkanthara, Arun.

Affiliation

Prasad A; Department of Oncology, Mayo Clinic, Rochester, MN, USA.
Kanakkanthara A; Department of Oncology, Mayo Clinic, Rochester, MN, USA; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA. Electronic address: Kanakkanthara.Arun@mayo.edu.

Trends Cell Biol ; 34(3): 173-175, 2024 03.

Article in En | MEDLINE | ID: mdl-38160123

ABSTRACT

ABSTRACT

How chromatin configuration impacts DNA repair is an emerging question. A recent study by Arnould et al. shows that ATM orchestrates a new chromatin compartment (D compartment) following DNA double-strand breaks and establishes that this compartment enhances cellular response to such breaks but also introduces a risk to genome integrity.

Subject(s)

Chromatin; DNA Repair; Humans; Ataxia Telangiectasia Mutated Proteins/genetics; Ataxia Telangiectasia Mutated Proteins/metabolism; DNA Breaks, Double-Stranded; DNA Damage

Key words

ATM; D compartment; DNA damage response; DNA repair; chromatin compartmentalization; genome integrity

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Chromatin / DNA Repair Limits: Humans Language: En Journal: Trends Cell Biol Year: 2024 Document type: Article Affiliation country: United States Country of publication: United kingdom

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