The prevalence of thyroid disorders in COVID-19 patients: a systematic review and meta-analysis.
BMC Endocr Disord
; 24(1): 5, 2024 Jan 02.
Article
in En
| MEDLINE
| ID: mdl-38166835
ABSTRACT
OBJECTIVES:
To conduct a systematic review and meta-analysis to evaluate the prevalence of thyroid disorders in COVID-19 patients. DATA SOURCES Scopus, PubMed, ISI Web of Science, and Google Scholar databases were used in this review. We also consider the results of grey literature. STUDY SELECTIONS Cohort, cross-sectional, and case-control studies were included. DATA EXTRACTION ANDSYNTHESIS:
The required data were extracted by the first author of the article and reviewed by the second author. The Pooled prevalence of outcomes of interest was applied using the meta-prop method with a pooled estimate after Freeman-Tukey Double Arcsine Transformation to stabilize the variances. OUTCOMES AND MEASURED The different thyroid disorders were the main outcomes of this study. The diseases include non-thyroidal illness syndrome, thyrotoxicosis, hypothyroidism, isolated elevated free T4, and isolated low free T4.RESULTS:
Eight articles were included in our meta-analysis(Totalparticipants:
1654). The pooled prevalence of events hypothyroidism, isolated elevated FT4, isolated low FT4, NTIS, and thyrotoxicosis were estimated (Pooled P = 3%, 95% CI2-5%, I2 78%), (Pooled P = 2%, 95% CI 0-4%, I2 66%), (Pooled P = 1%, 95% CI 0-1%, I2 0%), (Pooled P = 26%, 95% CI 10-42%, I2 98%), and (Pooled P = 10%, 95% CI 4-16%, I2 89%), respectively.CONCLUSION:
Thyroid dysfunction is common in COVID-19 patients, with a high prevalence of non-thyroidal illness syndrome (NTIS) and thyrotoxicosis. Our meta-analysis found a 26% prevalence of NTIS and a 10% prevalence of thyrotoxicosis. SYSTEMATIC REVIEW REGISTRATION PROSPERO CRD42022312601.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Thyroid Diseases
/
Euthyroid Sick Syndromes
/
Thyrotoxicosis
/
COVID-19
/
Hypothyroidism
Type of study:
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
/
Systematic_reviews
Limits:
Humans
Language:
En
Journal:
BMC Endocr Disord
Year:
2024
Document type:
Article
Affiliation country:
Iran