Adult respiratory distress syndrome: evidence of early fibrogenesis and absence of glucocorticoid receptors.
Eur J Respir Dis
; 69(4): 261-9, 1986 Oct.
Article
in En
| MEDLINE
| ID: mdl-3817060
ABSTRACT
In five lung biopsies from patients who developed the clinical picture of Adult Respiratory Distress Syndrome (ARDS) after cardiopulmonary bypass the pulmonary alterations were studied morphologically and glucocorticoid receptors determined. The time between cardiac surgery and pulmonary biopsy was 4-7 days. The results showed severe pulmonary lesions, with marked endothelial damage and active collagen secretion in the pulmonary interstitium, along the capillary bed. The glucocorticoid receptor level of the lungs with ARDS was 4.7 +/- 7.04 fmol/mg protein (control 4.28 +/- 4.32 fmol/mg protein). The results indicate that the process of collagen secretion may begin in the early phase of ARDS and that the benefits of glucocorticoid therapy in the management of ARDS should be reassessed.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pulmonary Fibrosis
/
Respiratory Distress Syndrome
/
Receptors, Glucocorticoid
/
Lung
Type of study:
Etiology_studies
Limits:
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Eur J Respir Dis
Year:
1986
Document type:
Article
Publication country:
DENMARK
/
DINAMARCA
/
DK