Your browser doesn't support javascript.
loading
Incident fractures of the distal radius: Dual-energy CT-derived metrics for opportunistic risk stratification.
Gruenewald, Leon D; Booz, Christian; Gotta, Jennifer; Reschke, Philipp; Martin, Simon S; Mahmoudi, Scherwin; Bernatz, Simon; Eichler, Katrin; D'Angelo, Tommaso; Chernyak, Victoria; Sommer, Christof M; Vogl, Thomas J; Koch, Vitali.
Affiliation
  • Gruenewald LD; Goethe University Frankfurt, University Hospital, Department of Diagnostic and Interventional Radiology, Frankfurt am Main, Germany.
  • Booz C; Goethe University Frankfurt, University Hospital, Department of Diagnostic and Interventional Radiology, Frankfurt am Main, Germany.
  • Gotta J; Goethe University Frankfurt, University Hospital, Department of Diagnostic and Interventional Radiology, Frankfurt am Main, Germany.
  • Reschke P; Goethe University Frankfurt, University Hospital, Department of Diagnostic and Interventional Radiology, Frankfurt am Main, Germany.
  • Martin SS; Goethe University Frankfurt, University Hospital, Department of Diagnostic and Interventional Radiology, Frankfurt am Main, Germany.
  • Mahmoudi S; Goethe University Frankfurt, University Hospital, Department of Diagnostic and Interventional Radiology, Frankfurt am Main, Germany.
  • Bernatz S; Goethe University Frankfurt, University Hospital, Department of Diagnostic and Interventional Radiology, Frankfurt am Main, Germany.
  • Eichler K; Goethe University Frankfurt, University Hospital, Department of Diagnostic and Interventional Radiology, Frankfurt am Main, Germany.
  • D'Angelo T; Department of Biomedical Sciences and Morphological and Functional Imaging, University Hospital Messina, Messina, Italy.
  • Chernyak V; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York City, NY, USA.
  • Sommer CM; Clinic of Diagnostic and Interventional Radiology, Heidelberg University Hospital, Heidelberg, Germany. Electronic address: cmsommer@gmx.com.
  • Vogl TJ; Goethe University Frankfurt, University Hospital, Department of Diagnostic and Interventional Radiology, Frankfurt am Main, Germany.
  • Koch V; Goethe University Frankfurt, University Hospital, Department of Diagnostic and Interventional Radiology, Frankfurt am Main, Germany.
Eur J Radiol ; 171: 111283, 2024 Feb.
Article in En | MEDLINE | ID: mdl-38183896
ABSTRACT

BACKGROUND:

Dual-energy CT (DECT)-derived bone mineral density (BMD) of the distal radius and other CT-derived metrics related to bone health have been suggested for opportunistic osteoporosis screening and risk evaluation for sustaining distal radius fractures (DRFs).

METHODS:

The distal radius of patients who underwent DECT between 01/2016 and 08/2021 was retrospectively analyzed. Cortical Hounsfield Unit (HU), trabecular HU, cortical thickness, and DECT-based BMD were acquired from a non-fractured, metaphyseal area in all examinations. Receiver-operating characteristic (ROC) analysis was conducted to determine the area under the curve (AUC) values for predicting DRFs based on DECT-derived BMD, HU values, and cortical thickness. Logistic regression models were then employed to assess the associations of these parameters with the occurrence of DRFs.

RESULTS:

In this study, 263 patients (median age 52 years; interquartile range 36-64; 132 women; 192 fractures) were included. ROC curve analysis revealed a higher area under the curve (AUC) value for DECT-derived BMD compared to cortical HU, trabecular HU, and cortical thickness (0.91 vs. 0.61, 0.64, and 0.69, respectively; p <.001). Logistic regression models confirmed the association between lower DECT-derived BMD and the occurrence of DRFs (Odds Ratio, 0.83; p <.001); however, no influence was observed for cortical HU, trabecular HU, or cortical thickness.

CONCLUSIONS:

DECT can be used to assess the BMD of the distal radius without dedicated equipment such as calibration phantoms to increase the detection rates of osteoporosis and stratify the individual risk to sustain DRFs. In contrast, assessing HU-based values and cortical thickness does not provide clinical benefit.
Subject(s)
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Osteoporosis / Fractures, Bone Type of study: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Female / Humans / Middle aged Language: En Journal: Eur J Radiol Year: 2024 Document type: Article Affiliation country: Germany

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Osteoporosis / Fractures, Bone Type of study: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Female / Humans / Middle aged Language: En Journal: Eur J Radiol Year: 2024 Document type: Article Affiliation country: Germany