Nickel-Catalyzed Electroreductive Coupling of Alkylpyridinium Salts and Aryl Halides.
ACS Catal
; 13(14): 9336-9345, 2023 Jul 21.
Article
in En
| MEDLINE
| ID: mdl-38188282
ABSTRACT
An electrochemical, nickel-catalyzed reductive coupling of alkylpyridinium salts and aryl halides is reported. High-throughput experimentation (HTE) was employed for rapid reaction optimization and evaluation of a broad scope of pharmaceutically relevant structurally diverse aryl halides, including complex drug-like substrates. In addition, the transformation is compatible with both primary and secondary alkylpyridinium salts with distinct conditions. Mechanistic insights were critical to enhance the efficiency of coupling using secondary alkylpyridinium salts. Systematic comparisons of the electrochemical and non-electrochemical methods revealed the complementary scope and efficiency of the two approaches.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
ACS Catal
Year:
2023
Document type:
Article
Affiliation country:
United States
Country of publication:
United States