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Novel and emerging drugs for the treatment of Crohn's disease: a review of phase II and III trials.
Wetwittayakhlang, Panu; Bessissow, Talat; Lakatos, Peter L.
Affiliation
  • Wetwittayakhlang P; Division of Gastroenterology and Hepatology, McGill University Health Center, Montreal, Quebec, Canada.
  • Bessissow T; Gastroenterology and Hepatology Unit, Division of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand.
  • Lakatos PL; Division of Gastroenterology and Hepatology, McGill University Health Center, Montreal, Quebec, Canada.
Expert Opin Emerg Drugs ; 29(1): 19-34, 2024 Mar.
Article in En | MEDLINE | ID: mdl-38193191
ABSTRACT

INTRODUCTION:

Crohn's disease (CD) is a chronic inflammatory bowel disease characterized by unpredictable flare-ups and periods of remission. While several therapeutic options, such as anti-tumor necrosis factor (TNF), anti-integrin, and interleukin (IL) 12/23 inhibitors, as well as IL-23 and Janus kinase (JAK) inhibitors, have been approved for CD treatment, a substantial number of patients fail to respond adequately or experience a loss of response over time. In recent years, the scientific community has been actively investigating novel agents to address these challenges and improve the management of CD. AREAS COVERED This comprehensive narrative review provides an overview of recent developments in CD treatment, summarizing phase 2 and phase 3 clinical trial data. We delve into the clinical efficacy and safety profiles of emerging therapies, encompassing JAK inhibitors, IL-23 inhibitors, anti-adhesion molecules, S1P1 receptor modulators, and combined targeted treatments. EXPERT OPINION The armamentarium of CD therapeutic agents is constantly expanding. We analyze pivotal findings from phase 2 and phase 3 CD treatment trials. We also underscore the existing gaps in therapy and the paramount role of ongoing research and innovation in CD management.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Crohn Disease Limits: Humans Language: En Journal: Expert Opin Emerg Drugs Journal subject: TERAPIA POR MEDICAMENTOS Year: 2024 Document type: Article Affiliation country: Canada Country of publication: United kingdom

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Crohn Disease Limits: Humans Language: En Journal: Expert Opin Emerg Drugs Journal subject: TERAPIA POR MEDICAMENTOS Year: 2024 Document type: Article Affiliation country: Canada Country of publication: United kingdom