[Advances in research on the role of immune cells in optic nerve injury].
Zhonghua Yan Ke Za Zhi
; 60(1): 95-101, 2024 Jan 11.
Article
in Zh
| MEDLINE
| ID: mdl-38199775
ABSTRACT
Optic nerve injury can result in the loss of retinal ganglion cells (RGCs) and their axons, representing a significant cause of irreversible vision impairment. Immune response is a common step following injury, and it often exhibits contrasting effects in optic nerve pathologies. Immune cells play a crucial role in this process, and understanding the differentiation of various immune cells post-injury, mitigating their neurotoxicity, and directing them towards a beneficial outcome for the protection of RGCs and axons are vital for optic nerve preservation. This paper provides a comprehensive review of the research progress on immune cells such as macrophages, microglia, T cells, and others in the field of optic nerve injury. Additionally, discussions include the identification of cell phenotypes and the exploration of the novel concept of innate immunity possibly possessing memory.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Optic Nerve Injuries
Limits:
Humans
Language:
Zh
Journal:
Zhonghua Yan Ke Za Zhi
Year:
2024
Document type:
Article
Affiliation country:
China