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Co-factor prosthesis facilitates biosynthesis of azido-pseudaminic acid probes for use as glycosyltransferase reporters.
Keenan, Tessa; Chidwick, Harriet S; Best, Matthew; Flack, Emily K P; Yates, Nicholas D J; Hatton, Natasha E; Warnes, Matthew E; Fascione, Martin A.
Affiliation
  • Keenan T; Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK. martin.fascione@york.ac.uk.
  • Chidwick HS; Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK. martin.fascione@york.ac.uk.
  • Best M; Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK. martin.fascione@york.ac.uk.
  • Flack EKP; Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK. martin.fascione@york.ac.uk.
  • Yates NDJ; Department of Biology, University of York, York, YO10 5DD, UK.
  • Hatton NE; Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK. martin.fascione@york.ac.uk.
  • Warnes ME; Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK. martin.fascione@york.ac.uk.
  • Fascione MA; Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK. martin.fascione@york.ac.uk.
Chem Commun (Camb) ; 60(11): 1428-1431, 2024 Feb 01.
Article in En | MEDLINE | ID: mdl-38205715
ABSTRACT
Truncated thioester N,S-diacetylcysteamine (SNAc) was utilised as a co-factor mimic for PseH, an acetyl-coA dependent aminoglycoside N-acetyltransferase, in the biosynthesis of the bacterial sugar, pseudaminic acid. Additionally, an azido-SNAc analogue was used to smuggle N7-azide functionality into the pseudaminic acid backbone, facilitating its use as a reporter of pseudaminyltransferase activity.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sugar Acids / Glycosyltransferases Language: En Journal: Chem Commun (Camb) / Chem. commun. (Lond., 1996, Online) / Chemical communications (London. 1996. Online) Journal subject: QUIMICA Year: 2024 Document type: Article Country of publication: United kingdom
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sugar Acids / Glycosyltransferases Language: En Journal: Chem Commun (Camb) / Chem. commun. (Lond., 1996, Online) / Chemical communications (London. 1996. Online) Journal subject: QUIMICA Year: 2024 Document type: Article Country of publication: United kingdom