Development of polypeptide-based materials toward messenger RNA delivery.
Nanoscale
; 16(5): 2250-2264, 2024 Feb 01.
Article
in En
| MEDLINE
| ID: mdl-38213302
ABSTRACT
Messenger RNA (mRNA)-based therapeutic agents have demonstrated significant potential in recent times, particularly in the context of the COVID-19 pandemic outbreak. As a promising prophylactic and therapeutic strategy, polypeptide-based mRNA delivery systems attract significant interest because of their low cost, simple preparation, tuneable sizes and morphology, convenient large-scale production, biocompatibility, and biodegradability. In this review, we begin with a brief discussion of the synthesis of polypeptides, followed by a review of commonly used polypeptides in mRNA delivery, including classical polypeptides and cell-penetrating peptides. Then, the challenges against mRNA delivery, including extracellular, intracellular, and clinical barriers, are discussed in detail. Finally, we highlight a range of strategies for polypeptide-based mRNA delivery, offering valuable insights into the advancement of polypeptide-based mRNA carrier development.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cell-Penetrating Peptides
/
Pandemics
Limits:
Humans
Language:
En
Journal:
Nanoscale
Year:
2024
Document type:
Article
Affiliation country:
United States
Country of publication:
United kingdom