The use of inhibition assay in Api g 7 suspected allergy in a female patient with anaphylaxis: A case report.
Int J Immunopathol Pharmacol
; 38: 3946320231223004, 2024.
Article
in En
| MEDLINE
| ID: mdl-38217433
ABSTRACT
The symptoms of celery allergy are mainly presented as oral allergy symptom, but there are several case reports of patients who experienced anaphylaxis. Defensin (Api g 7), as a novel allergen in celery root, was described in 2022 r. The female patient had a history of several episodes of dyspnea and cough, associated with ingestion of spice mixes containing dried celery. Up to the point of hospitalization, there were no objective tests, either sIgE or skin prick tests, that would confirm celery sensitization. During hospitalization, patient had a positive double-blind placebo-controlled food challenge with cooked celery. The patient was sensitized to mugwort defensin Art v 1. An inhibition assay with celery allergen extract was performed to prove cross-sensitization between Art v 1 and celery allergen responsible for symptoms in the patient. In conclusion, Api g 7 is an important celery allergen that can be responsible for severe reactions. Its cross-reactivity with Art v 1 is characteristic. Negative diagnostic tests with celery do not exclude Api g 7 sensitization.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Food Hypersensitivity
/
Anaphylaxis
Type of study:
Clinical_trials
/
Diagnostic_studies
Limits:
Female
/
Humans
Language:
En
Journal:
Int J Immunopathol Pharmacol
Journal subject:
ALERGIA E IMUNOLOGIA
/
FARMACOLOGIA
/
PATOLOGIA
Year:
2024
Document type:
Article
Affiliation country:
Poland