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In situ setup for screening of drug permeation by NMR spectroscopy.
Mildner, Malte; Hanio, Simon; Endres, Sebastian; Scheller, Lena; Engel, Bettina; Castañar, Laura; Meinel, Lorenz; Pöppler, Ann-Christin.
Affiliation
  • Mildner M; Institute of Organic Chemistry, University of Würzburg, Am Hubland, Würzburg 97074, Germany. ann-christin.poeppler@uni-wuerzburg.de.
  • Hanio S; Institute of Pharmacy and Food Chemistry, University of Würzburg, Am Hubland, Würzburg 97074, Germany.
  • Endres S; Institute of Organic Chemistry, University of Würzburg, Am Hubland, Würzburg 97074, Germany. ann-christin.poeppler@uni-wuerzburg.de.
  • Scheller L; Institute of Pharmacy and Food Chemistry, University of Würzburg, Am Hubland, Würzburg 97074, Germany.
  • Engel B; Institute of Pharmacy and Food Chemistry, University of Würzburg, Am Hubland, Würzburg 97074, Germany.
  • Castañar L; Department of Organic Chemistry, Faculty of Chemical Science, Complutense University of Madrid, Madrid, Spain.
  • Meinel L; Institute of Pharmacy and Food Chemistry, University of Würzburg, Am Hubland, Würzburg 97074, Germany.
  • Pöppler AC; Institute of Organic Chemistry, University of Würzburg, Am Hubland, Würzburg 97074, Germany. ann-christin.poeppler@uni-wuerzburg.de.
Anal Methods ; 16(10): 1468-1472, 2024 Mar 07.
Article in En | MEDLINE | ID: mdl-38226670
ABSTRACT
There are various commercially available setups for studying drug permeation, which differ in cost and manual labor. We explore an artificial membrane in an NMR tube to assess drug permeation with automated measurements. NMR-based concentrations were validated with HPLC and compared to a conventional setup. Setup-specific challenges and workarounds as well as future setup-designs for this and other applications are discussed.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Membranes, Artificial Type of study: Diagnostic_studies / Screening_studies Language: En Journal: Anal Methods Year: 2024 Document type: Article Affiliation country: Germany
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Membranes, Artificial Type of study: Diagnostic_studies / Screening_studies Language: En Journal: Anal Methods Year: 2024 Document type: Article Affiliation country: Germany