In situ setup for screening of drug permeation by NMR spectroscopy.
Anal Methods
; 16(10): 1468-1472, 2024 Mar 07.
Article
in En
| MEDLINE
| ID: mdl-38226670
ABSTRACT
There are various commercially available setups for studying drug permeation, which differ in cost and manual labor. We explore an artificial membrane in an NMR tube to assess drug permeation with automated measurements. NMR-based concentrations were validated with HPLC and compared to a conventional setup. Setup-specific challenges and workarounds as well as future setup-designs for this and other applications are discussed.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Membranes, Artificial
Type of study:
Diagnostic_studies
/
Screening_studies
Language:
En
Journal:
Anal Methods
Year:
2024
Document type:
Article
Affiliation country:
Germany