The classical and non-classical axes of renin-angiotensin system in Parkinson disease: The bright and dark side of the moon.
Ageing Res Rev
; 94: 102200, 2024 02.
Article
in En
| MEDLINE
| ID: mdl-38237699
ABSTRACT
Parkinson disease (PD) is a common brain neurodegenerative disease due to progressive degeneration of the dopaminergic neurons in the substantia nigra pars compacta (SNpc). Of note, the cardio-metabolic disorders such as hypertension are adversely affect PD neuropathology through exaggeration of renin-angiotensin system (RAS). The RAS affects the stability of dopaminergic neurons in the SNpc, and exaggeration of angiotensin II (AngII) is implicated in the development and progression of PD. RAS has two axes classical including angiotensin converting enzyme (ACE)/AngII/AT1R, and the non-classical axis which include ACE2/Ang1-7/Mas receptor, AngIII, AngIV, AT2R, and AT4R. It has been shown that brain RAS is differs from that of systemic RAS that produce specific neuronal effects. As well, there is an association between brain RAS and PD. Therefore, this review aims to revise from published articles the role of brain RAS in the pathogenesis of PD focusing on the non-classical pathway, and how targeting of this axis can modulate PD neuropathology.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Parkinson Disease
/
Neurodegenerative Diseases
/
Hypertension
Limits:
Humans
Language:
En
Journal:
Ageing Res Rev
Journal subject:
GERIATRIA
Year:
2024
Document type:
Article
Affiliation country:
Iraq
Country of publication:
United kingdom