Nutrient Sensing in Macrophages Linked to Reorganized Tumor Vasculature.
Cancer Res
; 84(5): 650-651, 2024 03 04.
Article
in En
| MEDLINE
| ID: mdl-38241708
ABSTRACT
Macrophages are plastic immune cells that have varying functions dependent on stimulation from their environment. In a recent issue of Immunity, Do and colleagues demonstrated that activating mechanistic target of rapamycin complex 1 signaling in tumor macrophages alters their metabolism, localization, and function. Specifically, these tumor macrophages promote vascular remodeling that develops a hypoxic environment toxic to cancer cells. This culminates in a tangible reduction in tumor burden in a murine model of breast cancer. Their findings reveal a unique strategy to promote vascular remodeling through macrophage polarization and thereby highlight the intimate connections between macrophage metabolism and function. Additionally, their model highlights parallels between tumor progression and wound healing contexts while emphasizing the amplified effect of small perturbations to a tumor ecosystem.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Ecosystem
/
Vascular Remodeling
Type of study:
Prognostic_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Cancer Res
Year:
2024
Document type:
Article
Country of publication:
United States