Making the connection: How membrane contact sites have changed our view of organelle biology.
Cell
; 187(2): 257-270, 2024 01 18.
Article
in En
| MEDLINE
| ID: mdl-38242082
ABSTRACT
The view of organelles and how they operate together has changed dramatically over the last two decades. The textbook view of organelles was that they operated largely independently and were connected by vesicular trafficking and the diffusion of signals through the cytoplasm. We now know that all organelles make functional close contacts with one another, often called membrane contact sites. The study of these sites has moved to center stage in cell biology as it has become clear that they play critical roles in healthy and developing cells and during cell stress and disease states. Contact sites have important roles in intracellular signaling, lipid metabolism, motor-protein-mediated membrane dynamics, organelle division, and organelle biogenesis. Here, we summarize the major conceptual changes that have occurred in cell biology as we have come to appreciate how contact sites integrate the activities of organelles.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Organelles
Language:
En
Journal:
Cell
Year:
2024
Document type:
Article
Country of publication:
United States