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Feasibility of PiB positron emission tomography/computed tomography for treatment monitoring with Tafamidis in a patient with transthyretin cardiac amyloidosis.
Fujioka, Kiriko; Norikane, Takashi; Takami, Yasukage; Yamamoto, Yuka; Noma, Takahisa; Nishiyama, Yoshihiro.
Affiliation
  • Fujioka K; Department of Radiology, Faculty of Medicine, Kagawa University, Kagawa, Japan.
  • Norikane T; Department of Radiology, Faculty of Medicine, Kagawa University, Kagawa, Japan. Electronic address: norikane.takashi.gv@kagawa-u.ac.jp.
  • Takami Y; Department of Radiology, Faculty of Medicine, Kagawa University, Kagawa, Japan.
  • Yamamoto Y; Department of Radiology, Faculty of Medicine, Kagawa University, Kagawa, Japan.
  • Noma T; Department of Cardiorenal and Cerebrovascular Medicine, Faculty of Medicine, Kagawa University, Kagawa, Japan.
  • Nishiyama Y; Department of Radiology, Faculty of Medicine, Kagawa University, Kagawa, Japan.
J Nucl Cardiol ; 33: 101816, 2024 Mar.
Article in En | MEDLINE | ID: mdl-38246259
ABSTRACT
We present a 77-year-old woman with wild-type ATTR cardiac amyloidosis (ATTR-CA) who presented with dyspnea, arrhythmia, and elevated NT-pro BNP. Initial imaging including cardiac MRI, PYP scintigraphy, PiB PET/CT and NaF PET/CT revealed cardiac abnormalities. Tafamidis treatment was initiated. After 14 months, symptomatic improvement and reduced NT-pro BNP were observed. Cardiac MRI and PYP scintigraphy showed no significant change and increased NaF accumulation, while PiB PET/CT showed decreased amyloid deposition, suggesting that it may be superior to NaF PET/CT in assessing the therapeutic effect of tafamidis in ATTR-CA.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzoxazoles / Amyloidosis / Cardiomyopathies Limits: Aged / Female / Humans Language: En Journal: J Nucl Cardiol Journal subject: CARDIOLOGIA Year: 2024 Document type: Article Affiliation country: Japan
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzoxazoles / Amyloidosis / Cardiomyopathies Limits: Aged / Female / Humans Language: En Journal: J Nucl Cardiol Journal subject: CARDIOLOGIA Year: 2024 Document type: Article Affiliation country: Japan