Feasibility of PiB positron emission tomography/computed tomography for treatment monitoring with Tafamidis in a patient with transthyretin cardiac amyloidosis.
J Nucl Cardiol
; 33: 101816, 2024 Mar.
Article
in En
| MEDLINE
| ID: mdl-38246259
ABSTRACT
We present a 77-year-old woman with wild-type ATTR cardiac amyloidosis (ATTR-CA) who presented with dyspnea, arrhythmia, and elevated NT-pro BNP. Initial imaging including cardiac MRI, PYP scintigraphy, PiB PET/CT and NaF PET/CT revealed cardiac abnormalities. Tafamidis treatment was initiated. After 14 months, symptomatic improvement and reduced NT-pro BNP were observed. Cardiac MRI and PYP scintigraphy showed no significant change and increased NaF accumulation, while PiB PET/CT showed decreased amyloid deposition, suggesting that it may be superior to NaF PET/CT in assessing the therapeutic effect of tafamidis in ATTR-CA.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Benzoxazoles
/
Amyloidosis
/
Cardiomyopathies
Limits:
Aged
/
Female
/
Humans
Language:
En
Journal:
J Nucl Cardiol
Journal subject:
CARDIOLOGIA
Year:
2024
Document type:
Article
Affiliation country:
Japan