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Chitosan­iodine complexes: Preparation, characterization, and antibacterial activity.
Zhang, Zhaoyu; Weng, Boya; Hu, Zhang; Si, Zhenyu; Li, Lefan; Yang, Ziming; Cheng, Yu.
Affiliation
  • Zhang Z; Faculty of Chemistry and Environmental Science, Guangdong Ocean University, Zhanjiang 524088, China.
  • Weng B; Faculty of Chemistry and Environmental Science, Guangdong Ocean University, Zhanjiang 524088, China.
  • Hu Z; Faculty of Chemistry and Environmental Science, Guangdong Ocean University, Zhanjiang 524088, China. Electronic address: huzhangqyx@126.com.
  • Si Z; Faculty of Chemistry and Environmental Science, Guangdong Ocean University, Zhanjiang 524088, China.
  • Li L; Faculty of Chemistry and Environmental Science, Guangdong Ocean University, Zhanjiang 524088, China.
  • Yang Z; South Subtropical Crop Research Institute, Chinese Academy of Tropical Agricultural Sciences, Zhanjiang 524001, China.
  • Cheng Y; Faculty of Chemistry and Environmental Science, Guangdong Ocean University, Zhanjiang 524088, China.
Int J Biol Macromol ; 260(Pt 2): 129598, 2024 Mar.
Article in En | MEDLINE | ID: mdl-38253142
ABSTRACT
Bacterial infections have always been a major threat to public health, and the development of effective antibacterial substances from natural polymers is crucial. 2-Aminoisonicotinic acid (AN) was grafted onto chitosan by 1-ethyl-(3-dimethylaminopropyl)carbodiimide-mediated coupling reactions, and then modified chitosan­iodine (CSAN-I) complexes were prepared by solvent-assisted grinding. The samples were characterized using ultraviolet-visible spectroscopy, Fourier transform infrared spectroscopy, Raman spectroscopy, proton nuclear magnetic resonance spectroscopy, and X-ray diffraction, confirming that CSAN-I complexes had been successfully prepared. Thermogravimetric (TG) analysis indicated that the chemical modification of chitosan and iodine complexation reduced the thermal stability; X-ray photoelectron spectroscopy (XPS) analysis revealed that 81 % of the iodine in CSAN-I complex was in the form of triiodide ions. The iodine contents of three CSAN-I complexes (CSAN-I-1, CSAN-I-2 and CSAN-I-3) were 1.59 ± 0.22 %, 3.18 ± 0.26 %, and 5.56 ± 0.41 %, respectively. The antibacterial effects were evaluated in vitro, and the results indicated that CSAN-I complexes had strong antibacterial activities against both E. coli and S. aureus. In particular, CSAN-I-3 exhibited the best antibacterial effect. In addition, CSAN-I-3 was nontoxic to L929 cells with good cytocompatibility. Therefore, CSAN-I complexes can be considered as promising candidates for wound management in clinical applications.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Chitosan / Iodine Language: En Journal: Int J Biol Macromol Year: 2024 Document type: Article Affiliation country: China Country of publication: Netherlands

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Chitosan / Iodine Language: En Journal: Int J Biol Macromol Year: 2024 Document type: Article Affiliation country: China Country of publication: Netherlands