Genome-Wide Genetic Associations Prioritize Evaluation of Causal Mechanisms of Atherosclerotic Disease Risk.
Arterioscler Thromb Vasc Biol
; 44(2): 323-327, 2024 02.
Article
in En
| MEDLINE
| ID: mdl-38266112
ABSTRACT
OBJECTIVE:
The goal of this review is to discuss the implementation of genome-wide association studies to identify causal mechanisms of vascular disease risk. APPROACH ANDRESULTS:
The history of genome-wide association studies is described, the use of imputation and the creation of consortia to conduct meta-analyses with sufficient power to arrive at consistent associated loci for vascular disease. Genomic methods are described that allow the identification of causal variants and causal genes and how they impact the disease process. The power of single-cell analyses to promote genome-wide association studies of causal gene function is described.CONCLUSIONS:
Genome-wide association studies represent a paradigm shift in the study of cardiovascular disease, providing identification of genes, cellular phenotypes, and disease pathways that empower the future of targeted drug development.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Vascular Diseases
/
Cardiovascular Diseases
Type of study:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Humans
Language:
En
Journal:
Arterioscler Thromb Vasc Biol
/
Arterioscler. thrombos. vasc. biol
/
Arteriosclerosis, thrombosis vascular biology
Journal subject:
ANGIOLOGIA
Year:
2024
Document type:
Article
Country of publication:
United States