Estimated Pulse Wave Velocity Predicts All-Cause and Cardiovascular-Cause Mortality in Individuals With Hypertensionã- Findings From a National Health and Nutrition Examination Study 1999-2018.
Circ J
; 88(3): 417-424, 2024 Feb 22.
Article
in En
| MEDLINE
| ID: mdl-38267051
ABSTRACT
BACKGROUND:
This study aimed to investigate the association between estimated pulse wave velocity (ePWV) and mortality outcomes among individuals with hypertension.MethodsâandâResults:
Based on the National Health and Nutrition Examination Survey (NHANES) 1999-2018, a total of 14,396 eligible participants with hypertension were enrolled. The ePWV was calculated using the equation based on blood pressure and age. The mortality outcomes of included participants were directly acquired from the National Death Index database. The multivariable Cox regression analysis was used to examine the relationship between ePWV and mortality outcomes. Moreover, the restricted cubic spline (RCS) was also used to explore this relationship. Receiver operating characteristics curves (ROC) were adopted to evaluate the prognostic ability of ePWV for predicting mortality outcomes of patients with hypertension. The median follow-up duration was 10.8 years; individuals with higher an ePWV had higher risks of mortality from both all causes (HR 2.79, 95% CI 2.43-3.20) and cardiovascular diseases (HR 3.41, 95% CI 2.50-4.64). After adjusting for confounding factors, each 1 m/s increase in ePWV was associated with a 43% increase in all-cause mortality risk (HR 1.43, 95% CI 1.37-1.48) and a 54% increase in cardiovascular mortality risk (HR 1.54, 95% CI 1.43-1.66).CONCLUSIONS:
This study indicates that ePWV is a novel prognostic indicator for predicting the risks of mortality among patients with hypertension.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cardiovascular Diseases
/
Cardiovascular System
/
Hypertension
Type of study:
Diagnostic_studies
/
Prognostic_studies
/
Risk_factors_studies
Aspects:
Patient_preference
Limits:
Humans
Language:
En
Journal:
Circ J
Journal subject:
ANGIOLOGIA
/
CARDIOLOGIA
Year:
2024
Document type:
Article