The Effect of the Ganglionic Segment Inflammatory Response to Postoperative Enterocolitis in Hirschsprung Disease.
Fetal Pediatr Pathol
; 43(2): 140-150, 2024.
Article
in En
| MEDLINE
| ID: mdl-38268442
ABSTRACT
INTRODUCTION:
We examined the relationship between proinflammatory cytokines that occur in the inflammatory reaction in the intestine in Hirschsprung disease (HD) and Hirschsprung-associated enterocolitis (HAEC).METHODS:
Thirty cases (M27, F3) operated on due to HD. The cases were divided into three groups group 1 with pre and post operative EC, group 2 with post-operative, and group 3 with pre-operative EC. The intestinal segments were evaluated by immunohistochemistry for interleukin 1 beta (IL-1ß), tumor necrosis factor-alpha (TNF-α), and interleukin 6 (IL-6).RESULTS:
IL-1ß staining was significantly higher in the ganglionic zone of groups with enterocolitis compared to the control group (p = 0.012). TNF-α staining in the transitional zone of Group 3 and IL-1ß staining in the ganglionic zone of Group 1 was significantly higher than the control group (p = 0.030, p = 0.020).CONCLUSION:
In our study, older age at diagnosis and more than 20% IL-1ß staining in the ganglionic segment were found to be risk factors for HAEC. It is noteworthy that the increase in IL-1ß can be associated with HAEC.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Enterocolitis
/
Hirschsprung Disease
Type of study:
Risk_factors_studies
Limits:
Humans
/
Infant
Language:
En
Journal:
Fetal Pediatr Pathol
Journal subject:
PATOLOGIA
/
PEDIATRIA
Year:
2024
Document type:
Article
Affiliation country:
Turkey