Fatty acid-binding protein-3 and renal function decline in patients with chronic coronary syndrome.
Clin Cardiol
; 47(1): e24210, 2024 Jan.
Article
in En
| MEDLINE
| ID: mdl-38269633
ABSTRACT
BACKGROUND:
Renal dysfunction is common in patients with coronary artery disease. Due to the shared vascular pathogenesis between the two conditions, novel biomarkers such as the fatty acid-binding protein-3 (FABP-3) have been proposed for diagnosis and prognosis prediction. This multicentre prospective cohort study investigates the association between FABP-3 and renal dysfunction.HYPOTHESIS:
We hypothesized that higher FABP-3 levels are correlated to worse renal outcome.METHODS:
Patients with chronic coronary syndrome were classified into three groups based on the initial serum FABP-3 levels. The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation was used to estimate the patient's renal function. Renal events were defined as >25% and >50% decline in estimated glomerular filtration rate (eGFR). Cox multivariable regression was employed to delineate the correlation between FABP-3 and renal dysfunction.RESULTS:
A total of 1606 subjects were included. During a mean follow-up of 35.9 months, there were 239 patients with eGFR >25% reduction and 60 patients with >50% reduction. In the Kaplan-Meier survival curve and log-rank test, increased levels of FABP-3 were significantly correlated with eGFR >25% reduction (p < .001) and >50% reduction (p < .001). Multivariate Cox regression model revealed that subjects with higher FABP-3 exhibited a greater risk of eGFR >25% reduction (Group 2 hazard ratio [HR] = 2.328, 95% confidence interval [CI] = 1.521-3.562, p < .001; Group 3 HR = 3.054, 95% CI = 1.952-4.776, p < .001) and >50% reduction (Group 3 HR = 4.838, 95% CI = 1.722-13.591, p = .003).CONCLUSIONS:
Serum FABP-3 may serve as a novel biomarker to predict eGFR decline in patients with chronic coronary syndrome.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Coronary Artery Disease
/
Renal Insufficiency, Chronic
/
Fatty Acid Binding Protein 3
Type of study:
Clinical_trials
/
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Humans
Language:
En
Journal:
Clin Cardiol
Year:
2024
Document type:
Article
Affiliation country:
Taiwan