The Expansion of Genetic Testing in Cardiovascular Medicine: Preparing the Cardiology Community for the Changing Landscape.
Curr Cardiol Rep
; 26(3): 135-146, 2024 03.
Article
in En
| MEDLINE
| ID: mdl-38277082
ABSTRACT
PURPOSE OF REVIEW Pathogenic DNA variants underlie many cardiovascular disease phenotypes. The most well-recognized of these include familial dyslipidemias, cardiomyopathies, arrhythmias, and aortopathies. The clinical presentations of monogenic forms of cardiovascular disease are often indistinguishable from those with complex genetic and non-genetic etiologies, making genetic testing an essential aid to precision diagnosis. RECENT FINDINGS:
Precision diagnosis enables efficient management, appropriate use of emerging targeted therapies, and follow-up of at-risk family members. Genetic testing for these conditions is widely available but under-utilized. In this review, we summarize the potential benefits of genetic testing, highlighting the specific cardiovascular disease phenotypes in which genetic testing should be considered, and how clinicians can integrate guideline-directed genetic testing into their practice.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cardiology
/
Cardiovascular Diseases
/
Cardiomyopathies
Type of study:
Guideline
Limits:
Humans
Language:
En
Journal:
Curr Cardiol Rep
Journal subject:
CARDIOLOGIA
Year:
2024
Document type:
Article
Affiliation country:
United States