Role of H3K4 monomethylation in gene regulation.
Curr Opin Genet Dev
; 84: 102153, 2024 02.
Article
in En
| MEDLINE
| ID: mdl-38278054
ABSTRACT
Methylation of histone H3 on the lysine-4 residue (H3K4me) is found throughout the eukaryotic domain, and its initial discovery as a conserved epigenetic mark of active transcription from yeast to mammalian cells has contributed to the histone code hypothesis. However, recent studies have raised questions on whether the different forms of H3K4me play a direct role in gene regulation or are simply by-products of the transcription process. Here, we review the often-conflicting experimental evidence, focusing on the monomethylation of lysine 4 on histone H3 that has been linked to the transcriptional state of enhancers in metazoans. We suggest that this epigenetic mark acts in a context-dependent manner to directly facilitate the transcriptional output of the genome and the establishment of cellular identity.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Histones
/
Lysine
Limits:
Animals
Language:
En
Journal:
Curr Opin Genet Dev
Journal subject:
GENETICA
Year:
2024
Document type:
Article