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Arctium lappa L. polysaccharides enhanced the therapeutic effects of nasal ectomesenchymal stem cells against liver fibrosis by inhibiting the Wnt/ß-catenin pathway.
Xiang, Wen; Yin, Guoliang; Liu, Haoming; Wei, Jiayi; Yu, Xinghui; Xie, Yan; Zhang, Li; Jiang, Wentao; Lu, Naiyan.
Affiliation
  • Xiang W; School of Medicine, Nankai University, Tianjin, China; Department of Liver Transplantation, Tianjin First Central Hospital, Tianjin, China; Tianjin Key Laboratory of Molecular and Treatment of Liver Cancer, Tianjin First Center Hospital, Tianjin, China.
  • Yin G; School of Food Science and Technology, Jiangnan University, Wuxi, China.
  • Liu H; School of Food Science and Technology, Jiangnan University, Wuxi, China.
  • Wei J; School of Food Science and Technology, Jiangnan University, Wuxi, China.
  • Yu X; School of Medicine, Nankai University, Tianjin, China; Department of Liver Transplantation, Tianjin First Central Hospital, Tianjin, China; Tianjin Key Laboratory of Molecular and Treatment of Liver Cancer, Tianjin First Center Hospital, Tianjin, China.
  • Xie Y; Department of Liver Transplantation, Tianjin First Central Hospital, Tianjin, China; Tianjin Key Laboratory of Molecular and Treatment of Liver Cancer, Tianjin First Center Hospital, Tianjin, China.
  • Zhang L; Department of Liver Transplantation, Tianjin First Central Hospital, Tianjin, China; Tianjin Key Laboratory of Molecular and Treatment of Liver Cancer, Tianjin First Center Hospital, Tianjin, China.
  • XueTang; School of Food Science and Technology, Jiangnan University, Wuxi, China.
  • Jiang W; School of Medicine, Nankai University, Tianjin, China; Department of Liver Transplantation, Tianjin First Central Hospital, Tianjin, China; Tianjin Key Laboratory of Molecular and Treatment of Liver Cancer, Tianjin First Center Hospital, Tianjin, China. Electronic address: jiangwentao@nankai.edu.cn.
  • Lu N; School of Food Science and Technology, Jiangnan University, Wuxi, China. Electronic address: lunaiyan@jiangnan.edu.cn.
Int J Biol Macromol ; 261(Pt 1): 129670, 2024 Mar.
Article in En | MEDLINE | ID: mdl-38280697
ABSTRACT
The oxidative microenvironment in fibrotic livers often diminishes the effectiveness of mesenchymal stem cells (MSCs)-based therapy. Recent research suggests that pharmacological pre-treatment could enhance the therapeutic performance of MSCs. In this study, we assessed the impact of Arctium lappa L. polysaccharides (ALP) on the biological properties of nasal ectomesenchymal stem cells (EMSCs) and investigated the augmenting effect of ALP pretreatment on EMSCs (ALP-EMSCs) for the treatment of liver fibrosis. ALP treatment demonstrated multiple biological impacts on EMSC functions regarding liver fibrosis firstly, it maintained the stemness of the cells while boosting the EMSCs' paracrine effects; secondly, it increased the expression of anti-inflammatory and antioxidant factors; thirdly, it inhibited the activation of hepatic stellate cells (HSCs) and liver collagen build-up by modulating the Wnt/ß-catenin signaling pathways. Collectively, these effects helped to halt the progression of liver fibrosis. Therefore, the use of ALP-EMSCs presents an innovative and promising approach for treating hepatic fibrosis in clinical scenarios.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arctium / Mesenchymal Stem Cells Limits: Humans Language: En Journal: Int J Biol Macromol Year: 2024 Document type: Article Affiliation country: China
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arctium / Mesenchymal Stem Cells Limits: Humans Language: En Journal: Int J Biol Macromol Year: 2024 Document type: Article Affiliation country: China