Mercaptopyrimidine-templated gold nanoclusters for antithrombotic therapy.
J Mater Chem B
; 12(7): 1775-1781, 2024 Feb 14.
Article
in En
| MEDLINE
| ID: mdl-38284142
ABSTRACT
Here we report for the first time that mercaptopyrimidine-templated gold nanoclusters (DAMP-AuNCs) can be used as a novel anticoagulant candidate for the design of antithrombotic drugs. Anticoagulant mechanisms revealed that DAMP-AuNCs significantly inhibited thrombus formation by interacting with fibrinogen. Carrageenan-induced mice tail thrombosis model experiments showed that DAMP-AuNCs had antithrombotic efficacy comparable to heparin in vivo. More importantly, these ultrasmall AuNCs possess excellent blood compatibility and only induce negligible bleeding side effects. Our study is a successful attempt at developing novel antithrombotic agents with high biosafety.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Fibrinolytic Agents
/
Gold
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
J Mater Chem B
Year:
2024
Document type:
Article
Affiliation country:
China
Country of publication:
United kingdom