Flavonoids and phenols from the stems of Ephedra equisetina.
Phytochemistry
; 220: 114003, 2024 Apr.
Article
in En
| MEDLINE
| ID: mdl-38301946
ABSTRACT
Twelve undescribed compounds, including five flavonoids and seven phenols, were isolated from the stems of Ephedra equisetina Bunge. Their structures were elucidated by spectroscopic methods, including NMR spectroscopy and HRESIMS analysis. Their absolute configurations were elucidated by comparing their experimental and calculated ECD spectra. In the in vitro bioactive assay, all compounds were tested for their anti-asthmatic activities by releasing ß-Hex in C48/80-induced RBL-2H3 cells. The ß-Hex release rates of compounds 3, 8, 10, and 11 were 0.8502 ± 0.0231, 0.8802 ± 0.0805, 0.7850 ± 0.0593, and 0.8361 ± 0.0728, respectively, suggesting that compounds 3, 8, 10, and 11 have potential anti-asthmatic activities.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Anti-Asthmatic Agents
/
Ephedra
/
Ephedra sinica
Language:
En
Journal:
Phytochemistry
Year:
2024
Document type:
Article
Affiliation country:
China