[Two Cases Suspected of Lynch Syndrome Caused by Juvenile Rectal Cancer].
Gan To Kagaku Ryoho
; 50(13): 1900-1902, 2023 Dec.
Article
in Ja
| MEDLINE
| ID: mdl-38303246
ABSTRACT
Case 1 A 28-year-old man was admitted to our hospital because of bloody stools that persisted for several months. Colonoscopy showed a 1/2 circumferential type 2 tumor in the rectum. Laparoscopic high anterior resection(D3)was performed for rectal cancer cT3N0M0, cStage â
¡a. The final diagnosis was pStage â
¡a, and MSI-high. XELOX therapy was performed for 3 months to prevent recurrence, and the patient is alive without recurrence. Case 2 A 51-year-old man, father of case 1 patient, was admitted to our hospital because of anemia and dyspnea. Colonoscopy showed a circumferential type 2 tumor in the ascending colon. Laparoscopic right hemicolectomy(D3)was performed for ascending colon cancer cT4b N2aM0, cStage â
¢c. The final diagnosis was pT3N0M0, pStage â
¡a, and MSI-high. The patient is alive no recurrence without adjuvant chemotherapy. Both patients had a family history of colorectal cancer, were MSI-high, met the Amsterdam criteria â
¡ and the revised Bethesda guidelines, and were suspected of having Lynch syndrome. A detailed family history and appropriate information provision were considered useful.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Rectal Neoplasms
/
Colorectal Neoplasms, Hereditary Nonpolyposis
/
Colonic Neoplasms
Type of study:
Diagnostic_studies
/
Guideline
Limits:
Adult
/
Humans
/
Male
/
Middle aged
Language:
Ja
Journal:
Gan To Kagaku Ryoho
Year:
2023
Document type:
Article
Country of publication:
Japan