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Cooperation between PRMT1 and PRMT6 drives lung cancer health disparities among Black/African American men.
Wu, Pei-Ying; Van Scoyk, Michelle; McHale, Stephanie S; Chou, Chu-Fang; Riddick, Gregory; Farouq, Kamran; Hu, Bin; Kraskauskiene, Vita; Koblinski, Jennifer; Lyons, Charles; Rijal, Arjun; Vudatha, Vignesh; Zhang, Dongyu; Trevino, Jose G; Shah, Rachit D; Nana-Sinkam, Patrick; Huang, Yong; Ma, Shwu-Fan; Noth, Imre; Hughes-Halbert, Chanita; Seewaldt, Victoria L; Chen, Ching-Yi; Winn, Robert A.
Affiliation
  • Wu PY; Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.
  • Van Scoyk M; Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.
  • McHale SS; Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.
  • Chou CF; Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.
  • Riddick G; Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.
  • Farouq K; Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.
  • Hu B; Department of Pathology and Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.
  • Kraskauskiene V; Department of Pathology and Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.
  • Koblinski J; Department of Pathology and Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.
  • Lyons C; Department of Pathology and Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.
  • Rijal A; Department of Pathology and Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.
  • Vudatha V; Division of Surgical Oncology and Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.
  • Zhang D; Division of Surgical Oncology and Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.
  • Trevino JG; Division of Surgical Oncology and Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.
  • Shah RD; Division of Cardiothoracic Surgery, Virginia Commonwealth University, Richmond, VA, USA.
  • Nana-Sinkam P; Division of Pulmonary Disease and Critical Care Medicine, Virginia Commonwealth University, Richmond, VA, USA.
  • Huang Y; Division of Pulmonary and Critical Care, University of Virginia, Charlottesville, VA, USA.
  • Ma SF; Division of Pulmonary and Critical Care, University of Virginia, Charlottesville, VA, USA.
  • Noth I; Division of Pulmonary and Critical Care, University of Virginia, Charlottesville, VA, USA.
  • Hughes-Halbert C; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA.
  • Seewaldt VL; City of Hope Comprehensive Cancer Center, Duarte, CA, USA.
  • Chen CY; Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.
  • Winn RA; Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.
iScience ; 27(2): 108858, 2024 Feb 16.
Article in En | MEDLINE | ID: mdl-38303720
ABSTRACT
Lung cancer is the third most common cancer with Black/AA men showing higher risk and poorer outcomes than NHW men. Lung cancer disparities are multifactorial, driven by tobacco exposure, inequities in care access, upstream health determinants, and molecular determinants including biological and genetic factors. Elevated expressions of protein arginine methyltransferases (PRMTs) correlating with poorer prognosis have been observed in many cancers. Most importantly, our study shows that PRMT6 displays higher expression in lung cancer tissues of Black/AA men compared to NHW men. In this study, we investigated the underlying mechanism of PRMT6 and its cooperation with PRMT1 to form a heteromer as a driver of lung cancer. Disrupting PRMT1/PRMT6 heteromer by a competitive peptide reduced proliferation in non-small cell lung cancer cell lines and patient-derived organoids, therefore, giving rise to a more strategic approach in the treatment of Black/AA men with lung cancer and to eliminate cancer health disparities.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Prognostic_studies Language: En Journal: IScience Year: 2024 Document type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Prognostic_studies Language: En Journal: IScience Year: 2024 Document type: Article Affiliation country: United States