Maternal occupational exposure to carbonaceous nanoscale particles and neurodevelopmental outcomes in early childhood: Analysis of the French Longitudinal Study of Children - Elfe study.
Environ Res
; 248: 118364, 2024 May 01.
Article
in En
| MEDLINE
| ID: mdl-38309566
ABSTRACT
OBJECTIVE:
To investigate the association between occupational exposures to carbonaceous unintentionally emitted nanoscale particles (UNPs) during pregnancy and the child's language development and behaviour at two years old.METHODS:
Using data from the French Longitudinal Study of Childhood - ELFE, we selected mothers who worked during pregnancy and their children. Exposure to carbonaceous UNPs was assessed by the MatPUF (job-exposure matrix for ultrafine particles). Children's lexical development was analysed using 'the Mac Arthur - Bates communicative development inventories-words and sentences-short form' (MB-CDI) in a multivariate binary logistic regression. Their risk for autism spectrum disorders was studied using 'the Modified-CHecklist for Autism in Toddler' (M-CHAT) according to the recommended thresholds (low risk = 0-2; intermediate risk = 3-6 and high risk = 7-23) in unordered multinomial logistic regression models.RESULTS:
Maternal occupational exposure to carbonaceous UNPs was associated with delayed child language development (ORadj 1.34; 95 % CI 1.00, 1.80) but not with behavioural disorders (autism spectrum disorders) at two years old.CONCLUSION:
This is the first epidemiological study to show a significant association between maternal occupational exposure to carbonaceous nanoscale particles and child language development at 2 years old.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Occupational Exposure
/
Nanoparticles
Type of study:
Observational_studies
/
Risk_factors_studies
Limits:
Child, preschool
/
Female
/
Humans
/
Pregnancy
Language:
En
Journal:
Environ Res
Year:
2024
Document type:
Article
Affiliation country:
France