Twice-Daily Proton Pump Inhibitor Induces Higher Remission Rate in Eosinophilic Esophagitis Than Once-Daily Regimen Regardless of Total Daily Dose.
Am J Gastroenterol
; 119(5): 991-995, 2024 05 01.
Article
in En
| MEDLINE
| ID: mdl-38314789
ABSTRACT
INTRODUCTION:
The optimal proton pump inhibitor (PPI) regimen for eosinophilic esophagitis (EoE) is unclear. We compared histologic response rates of different dosing combinations.METHODS:
A total of 305 patients with newly diagnosed EoE received standard (omeprazole 20 mg daily), once-daily moderate (40 mg daily), twice-daily moderate (20 mg twice daily), or high (40 mg twice daily) dose PPI for ≥8 weeks.RESULTS:
Approximately 42.3% achieved histologic response to PPI, with higher rates for twice-daily (moderate 52.8%/high 54.3%) than once-daily (standard 11.8%/moderate 10%) dosing ( P < 0.0001). On multivariable analysis, twice-daily moderate (adjusted odds ratio 6.75, confidence interval 2.53-18.0, P = 0.0008) and high (adjusted odds ratio 12.8, confidence interval 4.69-34.8, P < 0.0001) doses independently predicted histologic response.DISCUSSION:
Twice-daily PPI is associated with higher EoE histologic response rates than once-daily regimen.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Drug Administration Schedule
/
Proton Pump Inhibitors
/
Eosinophilic Esophagitis
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Am J Gastroenterol
/
Am. j. gastroenterol. (Online)
/
The American journal of gastroenterology (Online)
Year:
2024
Document type:
Article
Affiliation country:
United States
Country of publication:
United States