Comparison of methods for intravoxel incoherent motion parameter estimation in the brain from flow-compensated and non-flow-compensated diffusion-encoded data.
Magn Reson Med
; 92(1): 303-318, 2024 Jul.
Article
in En
| MEDLINE
| ID: mdl-38321596
ABSTRACT
PURPOSE:
Joint analysis of flow-compensated (FC) and non-flow-compensated (NC) diffusion MRI (dMRI) data has been suggested for increased robustness of intravoxel incoherent motion (IVIM) parameter estimation. For this purpose, a set of methods commonly used or previously found useful for IVIM analysis of dMRI data obtained with conventional diffusion encoding were evaluated in healthy human brain.METHODS:
Five methods for joint IVIM analysis of FC and NC dMRI data were compared (1) direct non-linear least squares fitting, (2) a segmented fitting algorithm with estimation of the diffusion coefficient from higher b-values of NC data, (3) a Bayesian algorithm with uniform prior distributions, (4) a Bayesian algorithm with spatial prior distributions, and (5) a deep learning-based algorithm. Methods were evaluated on brain dMRI data from healthy subjects and simulated data at multiple noise levels. Bipolar diffusion encoding gradients were used with b-values 0-200 s/mm2 and corresponding flow weighting factors 0-2.35 s/mm for NC data and by design 0 for FC data. Data were acquired twice for repeatability analysis.RESULTS:
Measurement repeatability as well as estimation bias and variability were at similar levels or better with the Bayesian algorithm with spatial prior distributions and the deep learning-based algorithm for IVIM parameters D $$ D $$ and f $$ f $$ , and for the Bayesian algorithm only for v d $$ {v}_d $$ , relative to the other methods.CONCLUSION:
A Bayesian algorithm with spatial prior distributions is preferable for joint IVIM analysis of FC and NC dMRI data in the healthy human brain, but deep learning-based algorithms appear promising.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Algorithms
/
Image Processing, Computer-Assisted
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Brain
/
Bayes Theorem
/
Diffusion Magnetic Resonance Imaging
/
Motion
Type of study:
Prognostic_studies
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
En
Journal:
Magn Reson Med
Journal subject:
DIAGNOSTICO POR IMAGEM
Year:
2024
Document type:
Article
Affiliation country:
Sweden
Country of publication:
United States