Plasma KL-6 as a Potential Biomarker for Bronchopulmonary Dysplasia in Preterm Infants.
Crit Care Res Pract
; 2024: 3623948, 2024.
Article
in En
| MEDLINE
| ID: mdl-38328675
ABSTRACT
Background:
KL-6 is a biomarker of interstitial lung injury and increases during repair.Aim:
Our aim was to determine the predictive value of plasma KL-6 for the development of bronchopulmonary dysplasia (BPD) in preterm infants.Methods:
Ninety-five extremely preterm infants (EPIs), born at <28 gestational age (GA), were divided into two main BPD groups as follows the moderate/severe and the no/mild group. KL-6 was analyzed on days 7 and 14. Binary logistic regression analyses and ROC curve analyses were performed.Results:
Infants <26 + 0 weeks' GA have higher mean KL-6 than infants >25 + 6 weeks' GA on 7 and 14 days (335 vs. 286 U/ml and 378 vs. 260 U/ml; p = 0.005 and 0.018, respectively). In the binary regression model at KL-6 day 7, three of the prognostic factors remained significant-mechanical ventilation OR 10.38 (95% CI 3.57-30.14), PDA OR 6.39 (95% CI 0.87-46.74), and KL-6 OR 4.98 (95% CI 1.54-16.08). The AUC was 0.86 with a sensitivity and specificity of 79% at a cutoff value ≥0.34. In the binary regression model at KL-6 day 14, six of the prognostic factors were significant-PDA OR 23.34 (95% CI 2.14-254.24), KL-6 OR 13.59 (95% CI 3.19-57.96), GA OR 4.58 (95% CI 1.16-18.06), mechanical ventilation OR 4.45 (95% CI 1.23-16.16), antenatal steroids OR 0.19 (95% CI 0.04-0.95), and gender (female OR 0.30 (95% CI 0.08-1.12)). The AUC was 0.91, and the sensitivity and accuracy for a cutoff ≥0.37 were 89% and 85%, respectively.Conclusion:
KL-6 could be a useful screening biomarker for early detection of infants at increased risk for developing BPD.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Type of study:
Prognostic_studies
/
Screening_studies
Language:
En
Journal:
Crit Care Res Pract
Year:
2024
Document type:
Article
Affiliation country:
Bulgaria
Country of publication:
Egypt