Fast and Stable Antibacterial Coating of Photosensitive Aggregation-Induced Emission Luminogens for Disinfection on Medical Devices.
Adv Healthc Mater
; 13(13): e2303967, 2024 05.
Article
in En
| MEDLINE
| ID: mdl-38334004
ABSTRACT
Aggregation-induced emission luminogens (AIEgens) are promising photosensitizers that have exhibited excellent antibacterial ability with abundant reactive oxygen species (ROS) generation. TTCPy-PF6 and TTCPy-Br are deposited on the surface of diverse solid substrates through plasma-assistant electrostatic self-assembly. The AIEgens-covered coating can effectively eliminate different pathogenic Gram-positive (G+) bacteria and even their multidrug-resistant (MDR) mutants with negligible side effects such as cytotoxicity, hemolysis, and inflammation. Moreover, the AIEgen-coated surface can maintain high stability for long-time antibacterial usage, which is dependent on the ROS-mediated disruption of the attached bacteria. The AIEgen-based coatings with broad surface applicability have many advantages in high antibacterial ability, great biocompatibility, and low possibility of antibiotic pollution. The robust antibacterial ability and excellent biological safety of the AIEgen-based coatings would be helpful for the disinfection of medical devices.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Disinfection
/
Photosensitizing Agents
/
Anti-Bacterial Agents
Limits:
Animals
/
Humans
Language:
En
Journal:
Adv Healthc Mater
Year:
2024
Document type:
Article
Country of publication:
Germany