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Trained immunity-inducing vaccines: Harnessing innate memory for vaccine design and delivery.
Baydemir, Ilayda; Dulfer, Elisabeth A; Netea, Mihai G; Domínguez-Andrés, Jorge.
Affiliation
  • Baydemir I; Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Nijmegen Medical Centre, 6500HB Nijmegen, the Netherlands.
  • Dulfer EA; Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Nijmegen Medical Centre, 6500HB Nijmegen, the Netherlands. Electronic address: elisabeth.dulfer@radboudumc.nl.
  • Netea MG; Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Nijmegen Medical Centre, 6500HB Nijmegen, the Netherlands; Department of Immunology and Metabolism, Life & Medical Sciences Institute, University of Bonn, Bonn, Germany.
  • Domínguez-Andrés J; Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Nijmegen Medical Centre, 6500HB Nijmegen, the Netherlands.
Clin Immunol ; 261: 109930, 2024 04.
Article in En | MEDLINE | ID: mdl-38342415
ABSTRACT
While the efficacy of many current vaccines is well-established, various factors can diminish their effectiveness, particularly in vulnerable groups. Amidst emerging pandemic threats, enhancing vaccine responses is critical. Our review synthesizes insights from immunology and epidemiology, focusing on the concept of trained immunity (TRIM) and the non-specific effects (NSEs) of vaccines that confer heterologous protection. We elucidate the mechanisms driving TRIM, emphasizing its regulation through metabolic and epigenetic reprogramming in innate immune cells. Notably, we explore the extended protective scope of vaccines like BCG and COVID-19 vaccines against unrelated infections, underscoring their role in reducing neonatal mortality and combating diseases like malaria and yellow fever. We also highlight novel strategies to boost vaccine efficacy, incorporating TRIM inducers into vaccine formulations to enhance both specific and non-specific immune responses. This approach promises significant advancements in vaccine development, aiming to improve global public health outcomes, especially for the elderly and immunocompromised populations.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Vaccines / COVID-19 Vaccines Limits: Aged / Humans / Newborn Language: En Journal: Clin Immunol Journal subject: ALERGIA E IMUNOLOGIA Year: 2024 Document type: Article Affiliation country: Netherlands Country of publication: United States

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Vaccines / COVID-19 Vaccines Limits: Aged / Humans / Newborn Language: En Journal: Clin Immunol Journal subject: ALERGIA E IMUNOLOGIA Year: 2024 Document type: Article Affiliation country: Netherlands Country of publication: United States