Silver nanoparticle reinforced polylactic acid and gelatin composite films for advanced wound dressing.
J Biomater Appl
; 38(8): 915-931, 2024 03.
Article
in En
| MEDLINE
| ID: mdl-38346020
ABSTRACT
Multifunctional and biodegradable dressings with high mechanical strength and good antibacterial activity are crucial in fundamental health services. This study was initiated to prepare a novel curative wound dressing film consisting of natural biodegradable gelatin (G) and polylactic acid (PLA) with silver nanoparticles (AgNPs) where glutaraldehyde (GA) was used as compatibilizer. The prepared composite films addressed the poor thermal and biological stability of G and the limited fluid retention capacity of PLA. Silver nanoparticles were prepared by basic chemical reduction and reinforced on polymer films using simple solvent casting, which obviated common clinical infections and accelerated wound closure rate (p < .05). Fourier transform infrared (FTIR) studies confirmed composite formation through H-bonding and X-ray diffraction (XRD) revealed increased crystallinity due to incorporating AgNPs. Films with G, PLA & GA (50505 by volume) introduced the best elasticity & strength with excellent fluid retention properties (p < .05). Scanning electron microscopy (SEM) images unfolded surface morphology and presence of agglomerated AgNPs on film surfaces. Prepared films exhibited significant antimicrobial efficacy against Staphylococcus aureus and Pseudomonas sp. and showed excellent cell viability (>97 %) in Vero cell line. Finally, an in vivo mouse model study showed 99.7 % contraction (p < .05) within 12 days, which was most effectual and 12 % faster than conventional gauge bandages. These results demonstrated the promising and cost-effective potential of the prepared film for wound healing.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Silver
/
Metal Nanoparticles
Limits:
Animals
Language:
En
Journal:
J Biomater Appl
Journal subject:
ENGENHARIA BIOMEDICA
Year:
2024
Document type:
Article
Affiliation country:
United States
Country of publication:
United kingdom