Epigenetic regulation as a therapeutic target in the malaria parasite Plasmodium falciparum.
Malar J
; 23(1): 44, 2024 Feb 12.
Article
in En
| MEDLINE
| ID: mdl-38347549
ABSTRACT
Over the past thirty years, epigenetic regulation of gene expression has gained increasing interest as it was shown to be implicated in illnesses ranging from cancers to parasitic diseases. In the malaria parasite, epigenetics was shown to be involved in several key steps of the complex life cycle of Plasmodium, among which asexual development and sexual commitment, but also in major biological processes like immune evasion, response to environmental changes or DNA repair. Because epigenetics plays such paramount roles in the Plasmodium parasite, enzymes involved in these regulating pathways represent a reservoir of potential therapeutic targets. This review focuses on epigenetic regulatory processes and their effectors in the malaria parasite, as well as the inhibitors of epigenetic pathways and their potential as new anti-malarial drugs. Such types of drugs could be formidable tools that may contribute to malaria eradication in a context of widespread resistance to conventional anti-malarials.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Parasites
/
Plasmodium
/
Malaria, Falciparum
/
Malaria
/
Antimalarials
Limits:
Animals
/
Humans
Language:
En
Journal:
Malar J
Journal subject:
MEDICINA TROPICAL
Year:
2024
Document type:
Article
Affiliation country:
France