Charge transfer complex-based spectrophotometric analysis of famotidine in pure and pharmaceutical dosage forms.
Sci Rep
; 14(1): 3661, 2024 02 13.
Article
in En
| MEDLINE
| ID: mdl-38351288
ABSTRACT
A straightforward and efficient spectrum technique was created using Ortho-chloranil as the electron acceptor (-acceptor) in a charge transfer (CT) complex formation reaction to determine the concentration of famotidine (FMD) in solutions. Compared to the double-distilled blank solution, the reaction result detected a definite violet colour at a maximum absorption wavelength of 546 nm, For concentrations range 2-28 µg/ml, the technique demonstrated excellent compliance with Beer-Law and Lambert's, as evidenced by its molar absorptivity of 2159.648 L mol-1 cm-1. Lower detection limits of 0.3024 µg/ml and 1.471 µg/ml, respectively, were discovered. The complexes of famotidine and Ortho-chloranil were found to have a 21 stoichiometry. Additionally, the suggested approach effectively estimated famotidine concentrations in pharmaceutical formulations, particularly in tablet form.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Famotidine
/
Chloranil
Language:
En
Journal:
Sci Rep
Year:
2024
Document type:
Article
Affiliation country:
Iraq