Iodoetherification as a strategy towards sp3-rich scaffolds for drug discovery.
Bioorg Med Chem
; 101: 117636, 2024 Mar 01.
Article
in En
| MEDLINE
| ID: mdl-38354458
ABSTRACT
Functionalised tetrahydropyran and spirooxepane scaffolds were prepared utilising an iodoetherification strategy and elaborated to demonstrate their potential use in library synthesis. The iodoetherification products could be readily transformed to the corresponding azides that could be further functionalised via copper-catalysed azide-alkyne cycloaddition or reduction to the amine. The lead-likeness and three-dimensionality of the scaffolds were examined and compared to commercial libraries.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Azides
/
Drug Discovery
Language:
En
Journal:
Bioorg Med Chem
Journal subject:
BIOQUIMICA
/
QUIMICA
Year:
2024
Document type:
Article
Affiliation country:
United kingdom