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Taxonomic and metabolic diversity of Actinomycetota isolated from faeces of a 28,000-year-old mammoth.
van Bergeijk, Doris A; Augustijn, Hannah E; Elsayed, Somayah S; Willemse, Joost; Carrión, Victor J; Du, Chao; Urem, Mia; Grigoreva, Lena V; Cheprasov, Maksim Y; Grigoriev, Semyon; Jansen, Hans; Wintermans, Bas; Budding, Andries E; Spaink, Herman P; Medema, Marnix H; van Wezel, Gilles P.
Affiliation
  • van Bergeijk DA; Department of Microbiology, Immunology and Transplantation (Laboratory of Molecular Bacteriology), KU Leuven, Leuven, Belgium.
  • Augustijn HE; Center for Microbiology, VIB, Leuven, Belgium.
  • Elsayed SS; Institute of Biology, Leiden University, Leiden, The Netherlands.
  • Willemse J; Bioinformatics Group, Wageningen University, Wageningen, The Netherlands.
  • Carrión VJ; Institute of Biology, Leiden University, Leiden, The Netherlands.
  • Du C; Institute of Biology, Leiden University, Leiden, The Netherlands.
  • Urem M; Institute of Biology, Leiden University, Leiden, The Netherlands.
  • Grigoreva LV; Department of Microbiology, University of Málaga, Málaga, Spain.
  • Cheprasov MY; Department of Microbial Ecology, Netherlands Institute of Ecology, Wageningen, The Netherlands.
  • Grigoriev S; Institute of Biology, Leiden University, Leiden, The Netherlands.
  • Jansen H; Institute of Biology, Leiden University, Leiden, The Netherlands.
  • Wintermans B; North-Eastern Federal University, Yakutsk, Russia.
  • Budding AE; North-Eastern Federal University, Yakutsk, Russia.
  • Spaink HP; North-Eastern Federal University, Yakutsk, Russia.
  • Medema MH; Future Genomics, Leiden, The Netherlands.
  • van Wezel GP; Department of Medical Microbiology, Adrz Hospital, Goes, The Netherlands.
Environ Microbiol ; 26(2): e16589, 2024 Feb.
Article in En | MEDLINE | ID: mdl-38356049
ABSTRACT
Ancient environmental samples, including permafrost soils and frozen animal remains, represent an archive with microbial communities that have barely been explored. This yet unexplored microbial world is a genetic resource that may provide us with new evolutionary insights into recent genomic changes, as well as novel metabolic pathways and chemistry. Here, we describe Actinomycetota Micromonospora, Oerskovia, Saccharopolyspora, Sanguibacter and Streptomyces species were successfully revived and their genome sequences resolved. Surprisingly, the genomes of these bacteria from an ancient source show a large phylogenetic distance to known strains and harbour many novel biosynthetic gene clusters that may well represent uncharacterised biosynthetic potential. Metabolic profiles of the strains display the production of known molecules like antimycin, conglobatin and macrotetrolides, but the majority of the mass features could not be dereplicated. Our work provides insights into Actinomycetota isolated from an ancient source, yielding unexplored genomic information that is not yet present in current databases.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Streptomyces / Actinomycetales / Mammoths Limits: Animals Language: En Journal: Environ Microbiol Journal subject: MICROBIOLOGIA / SAUDE AMBIENTAL Year: 2024 Document type: Article Affiliation country: Belgium

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Streptomyces / Actinomycetales / Mammoths Limits: Animals Language: En Journal: Environ Microbiol Journal subject: MICROBIOLOGIA / SAUDE AMBIENTAL Year: 2024 Document type: Article Affiliation country: Belgium