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Preparation, characterization, and evaluation of ketoconazole-loaded pineapple cellulose green nanofiber gel.
Rani, Pooja; Pahwa, Rimpy; Verma, Vikas; Bhatia, Meenakshi.
Affiliation
  • Rani P; Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar-125001, (Haryana), India.
  • Pahwa R; Amity Institute of Pharmacy, Amity University, Noida-201303, (Uttar Pradesh), India.
  • Verma V; Department of Chemistry, Guru Jambheshwar University of Science and Technology, Hisar-125001, (Haryana), India.
  • Bhatia M; Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar-125001, (Haryana), India. Electronic address: meenaxibhatia@gmail.com.
Int J Biol Macromol ; 262(Pt 2): 130221, 2024 Mar.
Article in En | MEDLINE | ID: mdl-38365159
ABSTRACT
The present study involves the isolation of cellulose nanofibers from pineapple crown waste by a combined alkali-acid treatment method. The extracted pineapple nanofibers were characterized by Fourier-transform infrared spectroscopy, differential scanning calorimetry, X-ray diffraction, scanning electron microscopy, nuclear magnetic resonance, high-resolution transmission electron microscopy, and dynamic light scattering. The extracted pineapple nanofibers were then incorporated in Carbopol 934P containing ketoconazole to prepare a ketoconazole-loaded pineapple nanofibrous gel. The prepared gel formulation was evaluated for viscosity, spreadability, extrudibility, pH, drug content, and texture profile analysis. The anticipated gel formulation was further evaluated by in vitro drug release (98.57 ± 0.58 %), ex vivo drug permeation, cytotoxicity, and histopathological studies. The permeation of the drug through skin determined by the ex-vivo diffusion study was found to be 38.27 % with a flux rate of 4.06 ± 0.26 µg/cm2/h. Further, the cytotoxicity study of pineapple nanofiber and ketoconazole-loaded nanofiber gel displayed no cytotoxic on healthy vero cells in the concentration range from 10 to 80 µg/ml. The histopathological analysis exhibited no signs of distress and inflammation. In conclusion, ketoconazole-loaded pineapple nanofiber gel could be considered as a promising delivery system for topical applications.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ananas / Nanofibers Limits: Animals Language: En Journal: Int J Biol Macromol Year: 2024 Document type: Article Affiliation country: India Country of publication: Netherlands

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ananas / Nanofibers Limits: Animals Language: En Journal: Int J Biol Macromol Year: 2024 Document type: Article Affiliation country: India Country of publication: Netherlands