Irreversible electroporation: Beyond the limits of tumor ablation.
Radiologia (Engl Ed)
; 66(1): 47-56, 2024.
Article
in En
| MEDLINE
| ID: mdl-38365354
ABSTRACT
Irreversible Electroporation (IRE) is a non-thermal tumor ablation technique. High-voltage electrical pulses are applied between pairs of electrodes inserted around and/or inside a tumor. The generated electric current induces the creation of nanopores in the cell membrane, triggering apoptosis. As a result, IRE can be safely used in areas near delicate vascular structures where other thermal ablation methods are contraindicated. Currently, IRE has demonstrated to be a successful ablation technique for pancreatic, renal, and liver tumors and is widely used as a focal therapeutic option for prostate cancer. The need for specific anesthetic management and accurate parallel placement of multiple electrodes entails a high level of complexity and great expertise from the interventional team is required. Nevertheless, IRE is a very promising technique with a remarkable systemic immunological capability and may impact on distant metastases (abscopal effect).
Key words
Ablation techniques; Electroporación; Electroporación irreversible; Electroporation; Immunotherapy; Inmunoterapia; Interventional; Irreversible electroporation therapy; Liver neoplasms; Medical oncology; Neoplasias hepáticas; Neoplasias pancreáticas; Neoplasias renales; Oncología; Pancreatic neoplasms; Radiology; Radiología; Radiología intervencionista; Renal neoplasm; Técnicas ablativas
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Prostatic Neoplasms
/
Ablation Techniques
/
Liver Neoplasms
Limits:
Humans
/
Male
Language:
En
Journal:
Radiologia (Engl Ed)
Year:
2024
Document type:
Article