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Multi-layered genome defences in bacteria.
Agapov, Aleksei; Baker, Kate S; Bedekar, Paritosh; Bhatia, Rama P; Blower, Tim R; Brockhurst, Michael A; Brown, Cooper; Chong, Charlotte E; Fothergill, Joanne L; Graham, Shirley; Hall, James Pj; Maestri, Alice; McQuarrie, Stuart; Olina, Anna; Pagliara, Stefano; Recker, Mario; Richmond, Anna; Shaw, Steven J; Szczelkun, Mark D; Taylor, Tiffany B; van Houte, Stineke; Went, Sam C; Westra, Edze R; White, Malcolm F; Wright, Rosanna.
Affiliation
  • Agapov A; ESI, Centre for Ecology and Conservation, University of Exeter, UK.
  • Baker KS; Department of Genetics, University of Cambridge, CB2 3EH, UK.
  • Bedekar P; ESI, Centre for Ecology and Conservation, University of Exeter, UK.
  • Bhatia RP; ESI, Centre for Ecology and Conservation, University of Exeter, UK.
  • Blower TR; Department of Biosciences, Durham University, Stockton Road, Durham DH1 3LE, UK.
  • Brockhurst MA; Division of Evolution, Infection and Genomics, School of Biological Sciences, University of Manchester, Dover Street, Manchester M13 9PT, UK.
  • Brown C; School of Biology, University of St Andrews, St Andrews KY16 9ST, UK.
  • Chong CE; Department of Genetics, University of Cambridge, CB2 3EH, UK.
  • Fothergill JL; Dept of Clinical Infection, Microbiology and Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, UK.
  • Graham S; School of Biology, University of St Andrews, St Andrews KY16 9ST, UK.
  • Hall JP; Dept of Evolution, Ecology and Behaviour, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, L69 7ZB, UK.
  • Maestri A; ESI, Centre for Ecology and Conservation, University of Exeter, UK.
  • McQuarrie S; School of Biology, University of St Andrews, St Andrews KY16 9ST, UK.
  • Olina A; ESI, Centre for Ecology and Conservation, University of Exeter, UK.
  • Pagliara S; LSI, University of Exeter, UK.
  • Recker M; ESI, Centre for Ecology and Conservation, University of Exeter, UK.
  • Richmond A; ESI, Centre for Ecology and Conservation, University of Exeter, UK.
  • Shaw SJ; DNA-Protein Interactions Unit, School of Biochemistry, University of Bristol, Bristol BS6 7YB, UK.
  • Szczelkun MD; DNA-Protein Interactions Unit, School of Biochemistry, University of Bristol, Bristol BS6 7YB, UK.
  • Taylor TB; Milner Centre for Evolution, Department of Life Sciences, University of Bath, Claverton Down, Bath BA2 7AY, UK.
  • van Houte S; ESI, Centre for Ecology and Conservation, University of Exeter, UK.
  • Went SC; Department of Biosciences, Durham University, Stockton Road, Durham DH1 3LE, UK.
  • Westra ER; ESI, Centre for Ecology and Conservation, University of Exeter, UK. Electronic address: E.R.Westra@exeter.ac.uk.
  • White MF; School of Biology, University of St Andrews, St Andrews KY16 9ST, UK.
  • Wright R; Division of Evolution, Infection and Genomics, School of Biological Sciences, University of Manchester, Dover Street, Manchester M13 9PT, UK.
Curr Opin Microbiol ; 78: 102436, 2024 04.
Article in En | MEDLINE | ID: mdl-38368839
ABSTRACT
Bacteria have evolved a variety of defence mechanisms to protect against mobile genetic elements, including restriction-modification systems and CRISPR-Cas. In recent years, dozens of previously unknown defence systems (DSs) have been discovered. Notably, diverse DSs often coexist within the same genome, and some co-occur at frequencies significantly higher than would be expected by chance, implying potential synergistic interactions. Recent studies have provided evidence of defence mechanisms that enhance or complement one another. Here, we review the interactions between DSs at the mechanistic, regulatory, ecological and evolutionary levels.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bacteriophages / CRISPR-Cas Systems Language: En Journal: Curr Opin Microbiol Journal subject: MICROBIOLOGIA Year: 2024 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bacteriophages / CRISPR-Cas Systems Language: En Journal: Curr Opin Microbiol Journal subject: MICROBIOLOGIA Year: 2024 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom