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External Urethral Sphincter Botulinum Toxin Injection to Treat Pseudodysynergia in Patients With Cerebral Palsy.
Haggart, Ryan; Loftus, Christopher J; DeWitt-Foy, Molly; Henry, Valencia; Grove, Shawn; Pariser, Joseph; Elliott, Sean.
Affiliation
  • Haggart R; Department of Urology, University of Minnesota, Minneapolis, MN. Electronic address: rhaggart@umn.edu.
  • Loftus CJ; Department of Urology, University of Minnesota, Minneapolis, MN.
  • DeWitt-Foy M; Glickman Urological & Kidney Institute, Cleveland Clinic, Cleveland, OH.
  • Henry V; Edward Via College of Osteopathic Medicine, Blacksburg, VA.
  • Grove S; Department of Urology, University of Minnesota, Minneapolis, MN.
  • Pariser J; Department of Urology, University of Minnesota, Minneapolis, MN.
  • Elliott S; Department of Urology, University of Minnesota, Minneapolis, MN.
Urology ; 186: 48-52, 2024 04.
Article in En | MEDLINE | ID: mdl-38387511
ABSTRACT

OBJECTIVE:

To evaluate urinary outcomes following cystoscopic external urinary sphincter onabotulinumtoxinA (BTX) injections in patients with cerebral palsy (CP). Adults with CP can suffer from bladder outlet obstruction and urinary retention due to a spastic external urethral sphincter ("pseudodysynergia"). We have used BTX injections into the sphincter to relieve the obstruction and allow patients to maintain spontaneous voiding rather than intermittent catheterization.

METHODS:

Patients were included in this retrospective cohort study if they had a diagnosis of CP, were at least 18 years of age, and underwent a urethral external sphincter BTX injection between 2016-2023. The procedure included 100 u or 200 u of BTX mixed in 4cc of saline. Primary outcomes were subjective, patient or caregiver reported changes in retention, lower urinary tract symptoms (LUTS), frequency of recurrent urinary tract infections (UTIs), and hydronephrosis or bladder stones/debris on ultrasound.

RESULTS:

Fifty patients were included; the majority were male (60%), lived at home with assistance (58%), and had a Gross Motor Function Classification System level of V (50%; ie, severe CP). The most common indications for BTX were retention (96%), LUTS (48%), hydronephrosis (18%), and recurrent UTIs (22%). Post-BTX improvement was seen in 67% of those with LUTS, 65% with retention, 67% with hydronephrosis, and 73% with recurrent UTIs. Most patients underwent repeat injections (60%). There were no significant complications associated with injections.

CONCLUSION:

External urethral sphincter BTX is a safe, effective option for treating pseudodysynergia in adults with CP.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cerebral Palsy / Botulinum Toxins, Type A / Lower Urinary Tract Symptoms / Hydronephrosis / Neuromuscular Agents Limits: Adult / Female / Humans / Male Language: En Journal: Urology Year: 2024 Document type: Article

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cerebral Palsy / Botulinum Toxins, Type A / Lower Urinary Tract Symptoms / Hydronephrosis / Neuromuscular Agents Limits: Adult / Female / Humans / Male Language: En Journal: Urology Year: 2024 Document type: Article
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