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Chemical Variability and Anti-Inflammatory Activity of Rosmarinus officinalis L. Leaf Essential Oil from Algerian Sahara.
Bekhechi, Ahlem; Malti, Charaf Eddine Watheq; Babali, Brahim; Bouafia, Miloud; Bekhechi, Chahrazed; Casanova, Joseph; Paoli, Mathieu; Tomi, Félix.
Affiliation
  • Bekhechi A; Université de Corse-CNRS, UMR 6134 SPE, Route des Sanguinaires, 20000, Ajaccio, France.
  • Malti CEW; Faculté des Sciences et Technologies, Université Ahmed Zabana, Cité Bourmadia, 48000, Relizane, Algérie.
  • Babali B; Laboratoire de Produits Naturels, Département de Biologie, Université Abou Bekr Belkaïd, Imama, 13000, Tlemcen, Algérie.
  • Bouafia M; Laboratoire d'Ecologie et Gestion des Ecosystèmes Naturels, Département d'Ecologie et Environnement, Université Abou Bekr Belkaïd, Imama, 13000, Tlemcen, Algérie.
  • Bekhechi C; Laboratoire Antibiotiques, Antifongiques, Physico-chimique, Synthèse et Activité Biologique, Département de Biologie, Université Abou Bekr Belkaïd, Imama, 13000, Tlemcen, Algérie.
  • Casanova J; Laboratoire de Produits Naturels, Département de Biologie, Université Abou Bekr Belkaïd, Imama, 13000, Tlemcen, Algérie.
  • Paoli M; Université de Corse-CNRS, UMR 6134 SPE, Route des Sanguinaires, 20000, Ajaccio, France.
  • Tomi F; Université de Corse-CNRS, UMR 6134 SPE, Route des Sanguinaires, 20000, Ajaccio, France.
Chem Biodivers ; 21(4): e202302077, 2024 Apr.
Article in En | MEDLINE | ID: mdl-38388803
ABSTRACT
The chemical composition of 71 oil samples from the leaves of Rosmarinus officinalis L., harvested in three provinces Naâma (Western Algeria), Béchar and Adrar (Algerian Sahara), was investigated by GC-FID, GC/MS and 13CNMR. In total, 52 compounds were identified accounting for 88.8 % to 99.9 % of the total composition. The chemical composition of the oils was largely dominated by monoterpenes, with 1,8-cineole (9.7-70.2 %), camphor (0.3-31.0 %) being the major compounds followed by borneol (0.3-21.0 %), α-pinene (4.5-14.5 %), ß-pinene (0.1-12.0 %), linalool (0.7-9.9 %) and verbenone (up to 11.1 %) which was present only in the samples harvested in Adrar. All compositions (71 samples) were submitted to statistical analysis. Combination of hierarchical clustering dendrogram and principal component analysis suggested the existence of three groups (one of these being subdivided into two sub-groups) which were distinguished on the basis of 1,8-cineole, camphor and verbenone contents. Four essential oil samples, containing 1,8-cineole and/or camphor as main components, exhibited anti-inflammatory activity against lipoxygenase, with IC50 values in the range 93 to 155 µg/mL.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oils, Volatile / Rosmarinus / Bicyclic Monoterpenes Country/Region as subject: Africa Language: En Journal: Chem Biodivers Journal subject: BIOQUIMICA / QUIMICA Year: 2024 Document type: Article Affiliation country: France

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oils, Volatile / Rosmarinus / Bicyclic Monoterpenes Country/Region as subject: Africa Language: En Journal: Chem Biodivers Journal subject: BIOQUIMICA / QUIMICA Year: 2024 Document type: Article Affiliation country: France