Crossprotection induced by virus-like particles containing influenza dual-hemagglutinin and M2 ectodomain.
Nanomedicine (Lond)
; 19(9): 741-754, 2024 04.
Article
in En
| MEDLINE
| ID: mdl-38390688
ABSTRACT
Aims:
To develop an effective universal vaccine against antigenically different influenza viruses. Materials &methods:
We generated influenza virus-like particles (VLPs) expressing the H1 and H3 antigens with or without M2e5x. VLP-induced immune responses and crossprotection against H1N1, H3N2 or H5N1 viruses were assessed to evaluate their protective efficacy.Results:
H1H3M2e5x immunization elicited higher crossreactive IgG antibodies than H1H3 VLPs. Upon challenge, both VLPs enhanced lung IgG, IgA and germinal center B-cell responses compared with control. While these VLPs conferred protection, H1H3M2e5x showed greater lung viral load reduction than H1H3 VLPs with minimal body weight loss.Conclusion:
Utilizing VLPs containing dual-hemagglutinin, along with M2e5x, can be a vaccination strategy for inducing crossprotection against influenza A viruses.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Influenza Vaccines
/
Orthomyxoviridae Infections
/
Influenza, Human
/
Influenza A Virus, H1N1 Subtype
/
Influenza A Virus, H5N1 Subtype
Limits:
Animals
/
Humans
Language:
En
Journal:
Nanomedicine (Lond)
Year:
2024
Document type:
Article
Country of publication:
United kingdom